ArticleVascular health and risk management2005
Serial changes in plasma levels of cytokines in patients with coronary artery disease.
Article in Vascular health and risk management, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Emerging Biomarkers and Electrochemical Biosensors for Early Detection of Premature Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Modifying Effect of the Interleukin-18 Level on the Association betweenInternational journal of molecular sciences · 2022Article
- Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease.PloS one · 2020Article
- Indoleamine 2,3-dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages.Research and practice in thrombosis and haemostasis · 2018Article
- Cyclic Nucleotide-Directed Protein Kinases in Cardiovascular Inflammation and Growth.Journal of cardiovascular development and disease · 2018Review
- Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective.Drug design, development and therapy · 2010 · on this mapReview
- Recent advances in the management of chronic stable angina I: approach to the patient, diagnosis, pathophysiology, risk stratification, and gender disparities.Vascular health and risk management · 2010Review
- Homocysteine and markers of inflammation in acute coronary syndrome.Experimental and clinical cardiology · 2010Article
- Photostable single-molecule nanoparticle optical biosensors for real-time sensing of single cytokine molecules and their binding reactions.Journal of the American Chemical Society · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInflammation is known to be a major determinant of the progression of coronary artery disease (CAD). In the present study we have evaluated the plasma levels of cytokines-tumor necrosis factor-alpha (TNF), interleukin- 1 alpha (IL-1), interleukin-6 (IL-6), interferon-gamma (IFN), and interleukin-10 (IL-10)- to examine the association between these cytokines and C-reactive protein (CRP) in patients with CAD.
methodsPatients with acute coronary syndromes (ACS; n = 20) were compared with patients with stable angina (SA; n= 20) and with control volunteers (C; n= 20). Blood samples were collected at the time of admission from all patients and 15 and 30 days thereafter.
resultsCRP levels (20.8+/-8.8 mg/L) (mean+/-SEM) were higher at baseline in ACS than SA patients (4.1+/-0.8mg/L) or the control subjects (5.1+/-1.8mg/L) (p<0.05). At admission, IL-6 was detected in 50% of the ACS patients and 5% of the SA patients or control subjects, while TNF was detected in 35% of the ACS and SA patients but only in 5% of control subjects. Subsequently, IL-6 levels declined and were no longer detectable, while TNF levels increased among ACS patients at all time periods tested when compared with other patients. The presence of IL-1 and IL-10 were not detectable in the blood samples examined, and IFN could only be detected in the ACS group. A significant correlation was observed between IL-6 and CRP levels (r=0.4; p<0.01) in all groups. There were no correlations among any of the other cytokines and CRP levels.
conclusionsOur study demonstrates raised levels of TNF, IL-6, IFN, and CRP in patients with ACS and a positive correlation between IL-6 and CRP but not with the other cytokines.
Indexed as
Identifiers
17319110PMC1993951W112000276What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.