ArticleChromosoma2007
Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes.
Article in Chromosoma, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Asymmetric centromere and gene locus positioning inbioRxiv : the preprint server for biology · 2025Article
- Regulation of condensin II by self-suppression and release mechanisms.Molecular biology of the cell · 2024Article
- A dual-function SNF2 protein drives chromatid resolution and nascent transcripts removal in mitosis.EMBO reports · 2023Article
- Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.Journal of cell science · 2021Article
- Article
- Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.Cell reports · 2020Article
- Polo regulates Spindly to prevent premature stabilization of kinetochore-microtubule attachments.The EMBO journal · 2020Article
- Mitotic chromosome organization: General rules meet species-specific variability.Computational and structural biotechnology journal · 2020Review
- Plant condensin II is required for the correct spatial relationship between centromeres and rDNA arrays.Nucleus (Austin, Tex.) · 2019Article
- Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion.Current biology : CB · 2018Article
- Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.The Journal of cell biology · 2018Article
- Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.Trends in genetics : TIG · 2018Review
- A Topology-Centric View on Mitotic Chromosome Architecture.International journal of molecular sciences · 2017Review
- The loading of condensin in the context of chromatin.Current genetics · 2017Review
- Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation.eLife · 2017Article
- Article
- Novel insights into mitotic chromosome condensation.F1000Research · 2016Review
- Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase.Cell reports · 2015Article
- Disruption of a conserved CAP-D3 threonine alters condensin loading on mitotic chromosomes leading to chromosome hypercondensation.The Journal of biological chemistry · 2015Article
- The maintenance of chromosome structure: positioning and functioning of SMC complexes.Nature reviews. Molecular cell biology · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The condensed state of mitotic chromosomes is crucial for faithful genome segregation. Key factors implicated in the formation of mitotic chromosomes are the condensin I and II complexes. In Drosophila, condensin I appears to play a major role in mitotic chromosome organization. To analyze its dynamic behavior, we expressed Barren, a condensin I non-Structural Maintenance of Chromosomes subunit, as a fully functional enhanced green fluorescent protein (EGFP) fusion protein in the female and followed it during early embryonic divisions. We find that, in Drosophila, Barren-EGFP associates with chromatin early in prophase concomitantly with the initiation of chromosome condensation. Barren-EGFP loading starts at the centromeric region from where it spreads distally reaching maximum accumulation at metaphase/early anaphase. Fluorescence Recovery After Photobleaching analysis indicates that most of the bound protein exchanges rapidly with the cytoplasmic pool during prometaphase/metaphase. Taken together, our results suggest that in Drosophila, condensin I is involved in the initial stages of chromosome condensation. Furthermore, the rapid turnover of Barren-EGFP indicates that the mechanism by which condensin I promotes mitotic chromosome organization is inconsistent with a static scaffold model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.