ArticleDiabetologia2007
Regulation of pancreatic islet cell survival and replication by gamma-aminobutyric acid.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Purification and Characterization of Gamma-Aminobutyric Acid (GABA) from E. faecium BS5 and Its Antidiabetic Efficacy in Streptozotocin-Induced Diabetic Rats.Probiotics and antimicrobial proteins · 2026Article
- Molecular cloning, characterization, and expression analysis of two GABAMolecular biology reports · 2026Article
- Article
- Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.American journal of physiology. Endocrinology and metabolism · 2021Review
- Insulin resistance and the role of gamma-aminobutyric acid.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- The Potential Role of Pancreatic γ-Aminobutyric Acid (GABA) in Diabetes Mellitus: A Critical Reappraisal.International journal of preventive medicine · 2021Review
- A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes HumanJournal of diabetes research · 2019Article
- Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication.Scientific reports · 2017Article
- Repurposing Lesogaberan to Promote Human Islet Cell Survival andJournal of diabetes research · 2017Article
- Recent progress in studies of factors that elicit pancreatic β-cell expansion.Protein & cell · 2015Review
- GABAergic system in the endocrine pancreas: a new target for diabetes treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Review
- Article
- Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.The open biochemistry journal · 2014Article
- Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique.PloS one · 2014Article
- Article
- Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.Endocrine reviews · 2013Review
- Paracrine interactions within islets of Langerhans.Journal of molecular neuroscience : MN · 2012Review
- GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells.PloS one · 2011Article
- Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisPancreatic islets have evolved remarkable, though poorly understood mechanisms to modify beta cell mass when nutrient intake fluctuates or cells are damaged. We hypothesised that appropriate and timely adjustments in cell number occur because beta cells release proliferative signals to surrounding cells when stimulated by nutrients and 'bleed' these growth factors upon injury. MATERIALS AND
methodsIn rat pancreatic islets, we measured DNA content, insulin content, insulin secretion after treatment, immunoblots of apoptotic proteins and the uptake of nucleoside analogues to assess the ability of gamma-aminobutyric acid (GABA), which is highly concentrated in beta cells, to act as a growth and survival factor. This focus is supported by work from others demonstrating that GABA increases cell proliferation in the developing nervous system, acts as a survival factor for differentiated neurons and, interestingly, protects plants under stress.
resultsOur results show that DNA, insulin content and insulin secretion are higher in freshly isolated islets treated with GABA or GABA B receptor agonists. Exposure to GABA upregulated the anti-apoptotic protein B-cell chronic lymphocytic leukaemia XL and limited activation of caspase 3 in islets. The cellular proliferation rate in GABA-treated islets was twice that of untreated controls. CONCLUSIONS/
interpretationWe conclude that GABA serves diverse purposes in the islet, meeting a number of functional criteria to act as an endogenous co-regulator of beta cell mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.