ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2007
Nail changes due to docetaxel--a neglected side effect and nuisance for the patient.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Dermatological adverse events with taxane chemotherapy.European journal of dermatology : EJD · 2016Pooled it
- A randomised controlled trial of interventions for taxane-induced nail toxicity in women with early breast cancer.Scientific reports · 2022Trial
- Comparison of patient reported quality of life and impact of treatment side effects experienced with a taxane-containing regimen and standard anthracycline based chemotherapy for early breast cancer: 6 year results from the UK TACT trial (CRUK/01/001).European journal of cancer (Oxford, England : 1990) · 2014Trial
- Prevention of taxane chemotherapy-induced nail changes and peripheral neuropathy by application of extremity cooling: a prospective single-centre study with intrapatient comparison.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Foot health and quality of life in women with breast cancer undergoing chemotherapy: a cross-sectional study.Journal of foot and ankle research · 2023Observational
- Foot Health in People with Cancer Undergoing Chemotherapy: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
- Narrative Review of Drug-Associated Nail Toxicities in Oncologic Patients.Dermatology practical & conceptual · 2023Review
- Study on Huangqi Bazhen Decoction on Relieving Chemotherapy Intestinal Mucositis in Capecitabine Gavage Mice.Contrast media & molecular imaging · 2022Article
- Dermatologic conditions in women receiving systemic cancer therapy.International journal of women's dermatology · 2019Review
- Prevalence of dermatological complaints in patients undergoing treatment for breast cancer.Anais brasileiros de dermatologia · 2018Observational
- The microbial flora of taxane therapy-associated nail disease in cancer patients.Journal of the American Academy of Dermatology · 2018Article
- New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles.Molecules (Basel, Switzerland) · 2016Article
- Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose.Cancer science · 2015Review
- Impact of Chemotherapy-Induced Nail Changes on Quality of Life: A Cross-Sectional Study from a Tertiary Care Centre.Indian journal of dermatologyArticle
- Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma.Indian dermatology online journalReview
- Nail Changes Induced by Chemotherapeutic Agents.Indian journal of dermatologyArticle
- Nail Changes With Chemotherapeutic Agents and Targeted Therapies.Indian dermatology online journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workThe objective of this study is to estimate the frequency and severity of nail changes due to treatment with the cytotoxic drug docetaxel and, secondly, to estimate how the nail changes effects the patients cosmetically and functionally in their daily activities. Finally, we want to clarify whether fungal infection could contribute in causing the nail changes. MATERIALS AND
methodsFifty-five patients with metastatic breast cancer in treatment with the cytotoxic drug docetaxel participated in the study. They filled out two questionnaires about their experience with possible nail changes. The frequency of fungal infection was examined. At each of the two visits, information about the number of treatment cycles, dose of docetaxel the patient received, frequency of lymph oedema, previous treatment with chemotherapy and the reason of discontinuance of treatment, if relevant, were registered. Finally, photos were taken to document the nail changes in hands and feet. MAIN
resultsFifty-eight percent had some degree of nail changes and an increase to 88.5% was seen after three additional cycles. A large proportion of the patients experienced the nail changes as a cosmetic nuisance, and more than 32% had functional problems.
conclusionNail changes occur more frequently than previous studies have shown. Furthermore, our study indicates that the nail changes are affecting a large proportion of the patients, both cosmetically and functionally, which may lead to a decrease in their quality of life. No significant association was found according to the possible relation between nail changes and fungal infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.