ArticlePsychopharmacology2007
Systemic administration of polyaminergic agents modulate fear conditioning in rats.
Article in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 39 citations in OpenAlex.
- Polyamines: Functions, Metabolism, and Role in Human Disease Management.Medical sciences (Basel, Switzerland) · 2021Review
- Spermidine, a positive modulator of the NMDA receptor, facilitates extinction and prevents the reinstatement of morphine-induced conditioned place preference in mice.Psychopharmacology · 2020Article
- Metabolomic study of polyamines in rat urine following intraperitoneal injection of γ-hydroxybutyric acid.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease.Frontiers in chemistry · 2018Review
- A Nonrewarding NMDA Receptor Antagonist Impairs the Acquisition, Consolidation, and Expression of Morphine Conditioned Place Preference in Mice.Molecular neurobiology · 2017Article
- Spermine reverses lipopolysaccharide-induced memory deficit in mice.Journal of neuroinflammation · 2015Article
- Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats.Psychopharmacology · 2011Article
- Arcaine and MK-801 make recall state-dependent in rats.Psychopharmacology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe polyamines putrescine, spermine, and spermidine are a group of aliphatic amines that physiologically modulate the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation.
objectivesGiven the potential application of these drugs in the treatment of memory disorders, we investigated whether agonists and/or antagonists of the NMDA receptor polyamine binding site alters the memory of fear conditioning and determined the time window in which fear conditioning is modulated by polyaminergic agents given by the systemic route.
resultsPost-training intraperitoneal administration of spermidine (10-100 mg/kg) immediately after training increased, whereas arcaine (10 mg/kg) and MK-801 (0.01-0.1 mg/kg) decreased contextual and auditory fear conditioning. Arcaine and MK-801, at doses that had no effect per se, reversed the facilitatory effect of spermidine. Memory of fear conditioning was impaired by polyaminergic blockade up to 180 min but not at 360 min after training.
conclusionThese results provide evidence that systemic administration of polyamine binding site ligands modulate early consolidation of fear conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.