ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2007
Introgressed and endogenous Mi-1 gene clusters in tomato differ by complex rearrangements in flanking sequences and show sequence exchange and diversifying selection among homologues.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 64 citations in OpenAlex.
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- Grasping Molecular Biology Mechanisms to Optimize Plant Resistance and Advance Microbiome Role Against Phytonematodes.International journal of molecular sciences · 2026Review
- Evaluation ofJournal of nematology · 2025Article
- Predicting Cloned Disease Resistance Gene Homologs (CDRHs) in Radish, Underutilised Oilseeds, and Wild Brassicaceae Species.Plants (Basel, Switzerland) · 2022Article
- Understanding Molecular Plant-Nematode Interactions to Develop Alternative Approaches for Nematode Control.Plants (Basel, Switzerland) · 2022Review
- TIR1/AFB proteins: Active players in abiotic and biotic stress signaling.Frontiers in plant science · 2022Review
- Tightly linked Rps12 and Rps13 genes provide broad-spectrum Phytophthora resistance in soybean.Scientific reports · 2021Article
- Building a cluster of NLR genes conferring resistance to pests and pathogens: the story of the Vat gene cluster in cucurbits.Horticulture research · 2021Article
- Metabolomics Approach for the Analysis of Resistance of Four Tomato Genotypes (Open life sciences · 2019Article
- Detection of an inversion in the Ty-2 region between S. lycopersicum and S. habrochaites by a combination of de novo genome assembly and BAC cloning.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments.Transgenic research · 2015Review
- Evolution of the Rdr1 TNL-cluster in roses and other Rosaceous species.BMC genomics · 2012Article
- Organization and molecular evolution of a disease-resistance gene cluster in coffee trees.BMC genomics · 2011Article
- Evolution of nematode-resistant Mi-1 gene homologs in three species of Solanum.Molecular genetics and genomics : MGG · 2011Article
- Comparative sequence analysis of the potato cyst nematode resistance locus H1 reveals a major lack of co-linearity between three haplotypes in potato (Solanum tuberosum ssp.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Fine mapping of the sunflower resistance locus Pl(ARG) introduced from the wild species Helianthus argophyllus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Sequence analysis of two alleles reveals that intra-and intergenic recombination played a role in the evolution of the radish fertility restorer (Rfo).BMC plant biology · 2010Article
- A novel approach to locate Phytophthora infestans resistance genes on the potato genetic map.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Isolation of a Ve homolog, mVe1, and its relationship to Verticillium wilt resistance in Mentha longifolia (L.) Huds.Molecular genetics and genomics : MGG · 2009Article
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3 authors at 3 institutions in 2 countries.
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Abstract
Many plant disease resistance genes (R-genes) encode proteins characterized by the presence of a nucleotide-binding site (NBS) and a leucine-rich repeat (LRR) region and occur in clusters of related genes in plant genomes. One such gene, Mi-1, confers isolate-specific resistance against root-knot nematodes, aphids and whiteflies in cultivated tomato, Solanum lycopersicon. The DNA region carrying Mi-1 and six closely related sequences was introgressed into tomato from Solanum peruvianum in the 1940s. For both susceptible and resistant tomato, Mi-1 homologues are present in two clusters with 3 and 4 copies each on the short arm of chromosome 6. Two homologues from each source are pseudogenes, and one homologue from each source encodes a truncated product. DNA sequence identity among the homologues including the truncated genes, but excluding the pseudogenes, ranges from 92.9 to 96.7%. All the non-pseudogene homologues are transcribed. Comparison of homologues suggests that extensive sequence exchange has occurred. Regions of diversifying selection are present in the ARC2 domain of the NBS region and dispersed throughout the LRR region, suggesting that these regions are possible locations of specificity determinants. Other sequences in the introgressed region have similarity to the Arabidopsis auxin-receptor protein TIR1, a jumonji-like transcription factor and a Na(+)/H(+) antiporter. Analysis of sequences flanking the Mi-1-homologues reveals blocks of homology, but complex differences in arrangement of these blocks when susceptible and resistant genotypes are compared indicating that the region has undergone considerable rearrangement during evolution, perhaps contributing to evolution of specificity.
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