ArticlePharmaceutical research2007
Surfactant-polymer nanoparticles: a novel platform for sustained and enhanced cellular delivery of water-soluble molecules.
Article in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 96 citations in OpenAlex.
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- Applications of nanomaterials in tissue engineering.RSC advances · 2021Review
- Synthesis and Characterization of Chitosan-Based Nanodelivery Systems to Enhance the Anticancer Effect of Sorafenib Drug in Hepatocellular Carcinoma and Colorectal Adenocarcinoma Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- Synthesis and evaluation of hydroponically alginate nanoparticles as novel carrier for intravenous delivery of propofol.Journal of materials science. Materials in medicine · 2015Article
- Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunities.Advanced drug delivery reviews · 2013Review
- Anticancer Activity of Nanoparticles Based on PLGA and its Co-polymer: In-vitro Evaluation.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Nanobarcoding: detecting nanoparticles in biological samples using in situ polymerase chain reaction.International journal of nanomedicine · 2012Article
- In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles.International journal of nanomedicine · 2012Article
- Transport of biological molecules in surfactant-alginate composite hydrogels.Acta biomaterialia · 2011Article
- Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications.Expert opinion on drug delivery · 2010Review
- Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNanoparticles, drug carriers in the sub-micron size range, can enhance the therapeutic efficacy of encapsulated drug by increasing and sustaining the delivery of the drug inside the cell. However, the use of nanoparticles for small molecular weight, water-soluble drugs has been limited by poor drug encapsulation efficiency and rapid release of the encapsulated drug. Here we report enhanced cellular delivery of water-soluble molecules using novel AerosolOT (AOT)-alginate nanoparticles recently developed in our laboratory. MATERIALS AND
methodsAOT-alginate nanoparticles were formulated using emulsion-crosslinking technology. Rhodamine and doxorubicin were used as model water-soluble molecules. Kinetics and mechanism of nanoparticle-mediated cellular drug delivery and therapeutic efficacy of nanoparticle-encapsulated doxorubicin were evaluated in two model breast cancer cell lines.
resultsAOT-alginate nanoparticles demonstrated sustained release of doxorubicin over a 15-day period in vitro. Cell culture studies indicated that nanoparticles enhanced the cellular delivery of rhodamine by about two-tenfold compared to drug in solution. Nanoparticle uptake into cells was dose-, time- and energy-dependent. Treatment with nanoparticles resulted in significantly higher cellular retention of drug than treatment with drug in solution. Cytotoxicity studies demonstrated that doxorubicin in nanoparticles resulted in significantly higher and more sustained cytotoxicity than drug in solution.
conclusionsAOT-alginate nanoparticles significantly enhance the cellular delivery of basic, water-soluble drugs. This translates into enhanced therapeutic efficacy for drugs like doxorubicin that have intracellular site of action. Based on these results, AOT-alginate nanoparticles appear to be suitable carriers for enhanced and sustained cellular delivery of basic, water-soluble drugs.
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