ArticleMolecular and cellular biochemistry2007
Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 104 citations in OpenAlex.
- Trypsin Digestion Conditions of Human Plasma for Observation of Peptides and Proteins from Tandem Mass Spectrometry.ACS omega · 2024Article
- Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells.Scientific reports · 2023Article
- AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration.Frontiers in molecular neuroscience · 2023Review
- Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule.Molecules (Basel, Switzerland) · 2022Review
- Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.Journal of the American Chemical Society · 2022Article
- Structural and Functional Studies ofMolecules (Basel, Switzerland) · 2022Article
- Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons.Translational psychiatry · 2021Article
- A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds.Molecular biology reports · 2021Review
- Influence of Piracetam on Gliclazide-Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study.Molecules (Basel, Switzerland) · 2018Article
- GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population.Molecular biology reports · 2018Article
- Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.International journal of molecular sciences · 2017Article
- Article
- Methylglyoxal-derived hydroimidazolone residue of plasma protein can behave as a predictor of prediabetes in Spontaneously Diabetic Torii rats.Physiological reports · 2015Article
- Glycated albumin: an overview of the In Vitro models of an In Vivo potential disease marker.Journal of diabetes and metabolic disorders · 2014Review
- Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species.Analytical chemistry · 2013Article
- Methylglyoxal, obesity, and diabetes.Endocrine · 2013Review
- Article
- Myoglobin-H2O2 catalyzes the oxidation of β-ketoacids to α-dicarbonyls: mechanism and implications in ketosis.Free radical biology & medicine · 2011Article
- Endogenous secretory receptor for advanced glycation end products and chronic kidney disease in the elderly population.American journal of nephrology · 2011Article
- Risk factors preceding type 2 diabetes and cardiomyopathy.Journal of cardiovascular translational research · 2010Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Diabetes Mellitus (DM), glucose and the aldehydes glyoxal and methylglyoxal modify free amino groups of lysine and arginine of proteins forming advanced glycation end products (AGEs). Elevated levels of these AGEs are implicated in diabetic complications including nephropathy. Our objective was to measure carboxymethyl cysteine (CMC) and carboxyethyl cysteine (CEC), AGEs formed by modification of free cysteine sulfhydryl groups of proteins by these aldehydes, in plasma proteins of patients with diabetes, and investigate their association with the albumin creatinine ratio (ACR, urine albumin (mg)/creatinine (mmol)), an indicator of nephropathy. Blood was collected from forty-two patients with type 1 and 2 diabetes (18-36 years) and eighteen individuals without diabetes (17-35 years). A liquid chromatography-mass spectrophotometric method was developed to measure plasma protein CMC and CEC levels. Values for ACR and hemoglobin A1C (HbA1C) were obtained. Mean plasma CMC (microg/l) and CEC (microg/l) were significantly higher in DM (55.73 +/- 29.43, 521.47 +/- 239.13, respectively) compared to controls (24.25 +/- 10.26, 262.85 +/- 132.02, respectively). In patients with diabetes CMC and CEC were positively correlated with ACR, as was HbA1C. Further, CMC or CEC in combination with HbA1C were better predictors of nephropathy than any one of these variables alone. These results suggest that glucose, glyoxal, and methylglyoxal may all be involved in the etiology of diabetic nephropathy.
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