ArticleInternational urology and nephrology2007
Serum and urine interleukin-6 and transforming growth factor-beta1 in young infants with pyelonephritis.
Article in International urology and nephrology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 9 citations in OpenAlex.
- Fully electronic urine dipstick probe for combinatorial detection of inflammatory biomarkers.Future science OA · 2018Article
- Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria.Central-European journal of immunology · 2016Article
- Lipopolysaccharide-binding protein: a potential marker of febrile urinary tract infection in childhood.Pediatric nephrology (Berlin, Germany) · 2013Article
- The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis.Pediatric nephrology (Berlin, Germany) · 2008Article
- Urinary excretion of EGF and MCP-1 in children with vesicoureteral reflux.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundCytokines are involved both in the acute response during pyelonephritis and in the progression to renal scarring. The aim of the present study was to assess the pro-inflammatory interleukin-6 (IL-6) and the anti-inflammatory pro-fibrotic transforming growth factor-beta1 (TGF-beta) in very young infants with pyelonephritis.
methodsSerum and urine concentrations of IL-6 and TGF-beta1 were determined by enzyme immunoassay in infants with acute pyelonephritis before antibiotic treatment and in infants with non-renal fever. IL-6 was studied in 12 infants with pyelonephritis and in eight with non-renal fever (median ages, 2 months for both groups). TGF-beta1 was studied in 11 infants with pyelonephritis and in nine with non-renal fever (median ages, 2 and 4 months, respectively).
resultsNo significant differences were documented in serum concentrations of IL-6 and TGF-beta1 between patients and controls. Urine IL-6 levels were significantly higher in infants with pyelonephritis than in controls (medians, 147 and 21.4 pg/ml, respectively; P = 0.0106). The urine levels of TGF-beta1 were lower in infants with pyelonephritis than in controls, although not significantly (medians, 6.12 and 11.0 ng/ml, respectively; P = 0.0705).
conclusionsOur findings confirm the implication of IL-6 but not of TGF-beta1 in the pathogenesis of the early stages of pyelonephritis in young infants. Tauhe role of the pro-fibrotic TGF-beta1 in the development of renal scarring deserves further investigation.
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