ArticleThe EMBO journal2007
The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022Review
- Axonal mRNA localization and translation: local events with broad roles.Cellular and molecular life sciences : CMLS · 2021Review
- Epigenome-wide study of brain DNA methylation following acute opioid intoxication.Drug and alcohol dependence · 2021Article
- Direct Interaction between Calmodulin and the Grb7 RA-PH Domain.International journal of molecular sciences · 2020Article
- Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.Cold Spring Harbor perspectives in biology · 2018Review
- Review
- Molecular determinants of the axonal mRNA transcriptome.Developmental neurobiology · 2014Review
- Grb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.Journal of molecular recognition : JMR · 2013Article
- Dimerization in the Grb7 protein.Journal of molecular recognition : JMR · 2012Article
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.Nature reviews. Neuroscience · 2012Review
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review.Clinical and experimental gastroenterology · 2012Article
- Transcriptional and epigenetic regulation of opioid receptor genes: present and future.Annual review of pharmacology and toxicology · 2011Review
- RhoA/ROCK1 signaling regulates stress granule formation and apoptosis.Cellular signalling · 2010Article
- Kappa opioid receptor contributes to EGF-stimulated neurite extension in development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Dual action of epidermal growth factor: extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA.The Journal of cell biology · 2010Article
- Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.The Journal of biological chemistry · 2009Article
- Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dynein motor contributes to stress granule dynamics in primary neurons.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported a novel biological activity of Netrin-1 in translational stimulation of kappa opioid receptor (KOR). We now identify Grb7 as a new RNA-binding protein that serves as the molecular adaptor for transmitting Netrin-1 signals, through focal adhesion kinase (FAK), to the translation machinery. Grb7 binds specifically to the first stem loop of kor mRNA 5'-UTR through a new RNA-binding domain located in its amino terminus. Upon binding to its capped, target mRNA, Grb7 blocks the recruitment of eIF4E, rendering mRNA untranslatable. The RNA-binding and translation-repressive activity is reduced by FAK-mediated hyperphosphorylation on two tyrosine residues of its carboxyl terminus. This study reports an adaptor protein Grb7 that transmits the stimulating signals of Netrin-1 to the translational machinery to rapidly regulate mRNA translation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.