ArticleThe EMBO journal2007
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025Article
- Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control.Frontiers of medicine · 2025Review
- Notch2 Signaling Drives Cardiac Hypertrophy by Suppressing Purine Nucleotide Metabolism.Research (Washington, D.C.) · 2025Article
- Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status.Scientific reports · 2024Article
- Article
- lncRNAProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.Nature cancer · 2021Article
- Review
- IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.Nature communications · 2018Article
- Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.Oncotarget · 2016Article
- Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.Oncotarget · 2015Article
- USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.Nature communications · 2014Article
- Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth.Molecular cancer therapeutics · 2013Article
- Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo.Cancer · 2013Article
- Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells.Cancer science · 2013Article
- Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.Oncogene · 2012Article
- Notch controls the magnitude of T helper cell responses by promoting cellular longevity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Induction of cancer cell death by isoflavone: the role of multiple signaling pathways.Nutrients · 2011Review
- Cleavage of Notch1 by granzyme B disables its transcriptional activity.The Biochemical journal · 2011Article
- Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling.Cancer informatics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological activity of Notch is a function of its ability to increase survival in many cell types. Several pathways have been shown to contribute to the survival effect of Notch, but the exact mechanism of Notch action is not completely understood. Here we identified that the regulation of cell survival by Notch intracellular domain could partly be attributed to a selective increase of X-linked inhibitor of apoptosis protein (XIAP). We further found that Notch intracellular domain inhibited the degradation of XIAP during apoptosis. The transactivation domain of Notch interacted directly with the RING region of XIAP to block the binding of E2 and prevent the in vivo and in vitro ubiquitination of XIAP. This antiapoptotic activity of Notch was abolished when XIAP was knocked down. Our results reveal a novel mechanism for Notch-selective suppression of apoptosis through an increase in the stability of a key antiapoptotic protein, XIAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.