ArticleThe Journal of physiology2007
Increases in central blood volume modulate carotid baroreflex resetting during dynamic exercise in humans.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Differential effects of central blood volume loading and unloading on pulmonary diffusing capacity in humans.The Journal of physiology · 2026Article
- Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals.The journal of physiological sciences : JPS · 2024Article
- Cardiovascular responses to leg-press exercises during head-down tilt.Frontiers in sports and active living · 2024Article
- Autonomic cardiovascular control during exercise.American journal of physiology. Heart and circulatory physiology · 2023Review
- Central command suppresses pressor-evoked bradycardia at the onset of voluntary standing up in conscious cats.Experimental physiology · 2023Article
- Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation.The Journal of physiology · 2022Review
- A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise.European journal of applied physiology · 2022Review
- Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.Comprehensive Physiology · 2021Article
- Neurovascular Dysregulation During Exercise in Type 2 Diabetes.Frontiers in physiology · 2021Review
- Muscle sympathetic nerve activity during exercise.The journal of physiological sciences : JPS · 2019Review
- High-intensity muscle metaboreflex activation attenuates cardiopulmonary baroreflex-mediated inhibition of muscle sympathetic nerve activity.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Effect of centrally acting angiotensin converting enzyme inhibitor on the exercise-induced increases in muscle sympathetic nerve activity.The Journal of physiology · 2018Article
- Neural control of circulation and exercise: a translational approach disclosing interactions between central command, arterial baroreflex, and muscle metaboreflex.American journal of physiology. Heart and circulatory physiology · 2015Review
- Cardiovascular Reflexes Activity and Their Interaction during Exercise.BioMed research international · 2015Review
- Enhanced muscle pump during mild dynamic leg exercise inhibits sympathetic vasomotor outflow.Physiological reports · 2014Article
- New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.Autonomic neuroscience : basic & clinical · 2012Review
- Human investigations into the arterial and cardiopulmonary baroreflexes during exercise.Experimental physiology · 2012Review
- Carotid baroreflex control of arterial blood pressure at rest and during dynamic exercise in aging humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We sought to determine if resetting of the carotid-vasomotor baroreflex function curve during exercise is modulated by changes in central blood volume (CBV). CBV was increased during exercise by altering: (1) subject posture (supine versus upright) and (2) pedal frequency (80 versus 60 revolutions min(-1) (r.p.m.)); while oxygen uptake ( ) was kept constant. Eight male subjects performed three exercise trials: upright cycling at 60 r.p.m. (control); supine cycling at 60 r.p.m. (SupEX) and upright cycling at 80 r.p.m. to enhance the muscle pump (80EX). During each condition, carotid baroreflex (CBR) function was determined using the rapid neck pressure (NP) and neck suction (NS) protocol. Although mean arterial pressure (MAP) was significantly elevated from rest (88 +/- 2 mmHg) during all exercise conditions (P < 0.001), the increase in MAP was lower during SupEX (94 +/- 2 mmHg) and 80EX (95 +/- 2 mmHg) compared with control (105 +/- 2 mmHg, P < 0.05). Importantly, the blood pressure responses to NP and NS were maintained around these changed operating points of MAP. However, in comparison to control, the carotid-vasomotor baroreflex function curve was relocated downward and leftward when CBV was increased during SupEX and 80EX. These alterations in CBR resetting occurred without any differences in or heart rate between the exercise conditions. Thus, increasing CBV and loading the cardiopulmonary baroreflex reduces the magnitude of exercise-induced increases in MAP and CBR resetting. These findings suggest that changes in cardiopulmonary baroreceptor load influence carotid baroreflex resetting during dynamic exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.