Trial reportThe Journal of physiology2007
Effects of hypoxia on diaphragmatic fatigue in highly trained athletes.
Trial report in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of 5-Wk Repeated Sprint Training in Hypoxia on Global Inspiratory and Core Muscle Functions.Journal of sports science & medicine · 2024Trial
- Respiratory muscle endurance training: effect on normoxic and hypoxic exercise performance.European journal of applied physiology · 2010Trial
- Combined effects of normobaric hypoxia and cold on respiratory system responses to high-intensity exercise.Experimental physiology · 2025Article
- Respiratory system responses to a maximal apnoea.Experimental physiology · 2025Review
- The Relationship between Inspiratory Muscle Strength and Cycling Performance: Insights from Hypoxia and Inspiratory Muscle Warm-Up.Journal of functional morphology and kinesiology · 2024Article
- Effects of hypoxia on exercise-induced diaphragm fatigue in healthy males and females.Physiological reports · 2023Article
- Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses.Physiological reports · 2021Article
- Scalene and sternocleidomastoid activation during normoxic and hypoxic incremental inspiratory loading.Physiological reports · 2020Article
- Putative Role of Respiratory Muscle Training to Improve Endurance Performance in Hypoxia: A Review.Frontiers in physiology · 2018Review
- Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength.Hypoxia (Auckland, N.Z.) · 2017Review
- Effect of acute hypoxia on inspiratory muscle oxygenation during incremental inspiratory loading in healthy adults.European journal of applied physiology · 2016Article
- High-Intensity Inspiratory Protocol Increases Heart Rate Variability in Myocardial Revascularization Patients.Brazilian journal of cardiovascular surgery · 2016Article
- Effect of acute hypoxia on respiratory muscle fatigue in healthy humans.Respiratory research · 2010Article
- Intercostal muscle blood flow limitation in athletes during maximal exercise.The Journal of physiology · 2009Article
- Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue in trained cyclists.The Journal of physiology · 2008Article
- The contribution of intrapulmonary shunts to the alveolar-to-arterial oxygen difference during exercise is very small.The Journal of physiology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous work suggests that exercise-induced arterial hypoxaemia (EIAH), causing only moderate arterial oxygen desaturation (SaO2 : 92 +/- 1%), does not exaggerate diaphragmatic fatigue exhibited by highly trained endurance athletes. Since changes in arterial O2 tension have a significant effect on the rate of development of locomotor muscle fatigue during strenuous exercise, the present study investigated whether hypoxia superimposed on EIAH exacerbates the exercise-induced diaphragmatic fatigue in these athletes. Eight trained cyclists (VO2max : 67.0 +/- 2.6 ml kg(-1) min(-1); mean +/- S.E.M.) completed in balanced order four 5 min exercise tests leading to different levels of end-exercise SaO2 (64 +/- 2, 83 +/- 1, 91 +/- 1 and 96 +/- 1%) via variations in inspired O2 fraction (FiO2 : 0.13, 0.17, 0.21 and 0.26, respectively). Measurements were made at corresponding intensities (65 +/- 3, 80 +/- 3, 85 +/- 3 and 90 +/- 3% of normoxic maximal work rate, respectively) in order to produce the same tidal volume, breathing frequency and respiratory muscle load at each FiO2. The mean pressure time product of the diaphragm did not differ across the four exercise tests and ranged between 312 +/- 28 and 382 +/- 22 cmH2O s min(-1). Ten minutes into recovery, twitch transdiaphragmatic pressure (P(di,tw)) determined by bilateral phrenic nerve stimulation, was significantly (P = 0.0001) reduced after all tests. After both hypoxic tests (FiO2 : 0.13, 0.17) the degree of fall in P(di,tw) (by 26.9 +/- 2.7 and 27.4 +/- 2.6%, respectively) was significantly greater (P < 0.05) than after the normoxic test (by 20.1 +/- 3.4%). The greater amount of diaphragmatic fatigue in hypoxia at lower leg work rates (presumably requiring smaller leg blood flow compared with normoxia at higher leg work rates), suggests that when ventilatory muscle load is similar between normoxia and hypoxia, hypoxia exaggerates diaphragmatic fatigue in spite of potentially greater respiratory muscle blood flow availability.
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