ArticleThe Journal of physiology2007
Dendritic D-type potassium currents inhibit the spike afterdepolarization in rat hippocampal CA1 pyramidal neurons.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- Targeting heterozygous dominant negative variant ofMolecular therapy. Nucleic acids · 2024Article
- Location, location, location: the organization and roles of potassium channels in mammalian motoneurons.The Journal of physiology · 2021Article
- Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy.Biophysical journal · 2020Article
- Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.PloS one · 2020Article
- Functional roles of Kv1-mediated currents in genetically identified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex.Journal of neurophysiology · 2018Article
- Characterizing Concentration-Dependent Neural Dynamics of 4-Aminopyridine-Induced Epileptiform Activity.Epilepsy journal · 2018Article
- The role of axonal Kv1 channels in CA3 pyramidal cell excitability.Scientific reports · 2017Article
- Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E.The Journal of physiology · 2017Article
- mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Frontiers in cellular neuroscience · 2017Article
- Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.Nature communications · 2016Article
- REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.Cell death and differentiation · 2015Article
- Role of small conductance Ca²⁺-activated K⁺ channels in controlling CA1 pyramidal cell excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activation of 5-HT2A receptors by TCB-2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro.Physiological reports · 2014Article
- Spike-timing control by dendritic plateau potentials in the presence of synaptic barrages.Frontiers in computational neuroscience · 2014Article
- Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.The Journal of cell biology · 2013Article
- Article
- High frequency stimulation can suppress globally seizures induced by 4-AP in the rat hippocampus: an acute in vivo study.Brain stimulation · 2013Article
- Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy.Frontiers in cellular neuroscience · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In CA1 pyramidal neurons, burst firing is correlated with hippocampally dependent behaviours and modulation of synaptic strength. One of the mechanisms underlying burst firing in these cells is the afterdepolarization (ADP) that follows each action potential. Previous work has shown that the ADP results from the interaction of several depolarizing and hyperpolarizing conductances located in the soma and the dendrites. By using patch-clamp recordings from acute rat hippocampal slices we show that D-type potassium current modulates the size of the ADP and the bursting of CA1 pyramidal neurons. Sensitivity to alpha-dendrotoxin suggests that Kv1-containing potassium channels mediate this current. Dual somato-dendritic recording, outside-out dendritic recordings, and focal application of dendrotoxin together indicate that the channels mediating this current are located in the apical dendrites. Thus, our data present evidence for a dendritic segregation of Kv1-like channels in CA1 pyramidal neurons and identify a novel action for these channels, showing that they inhibit action potential bursting by restricting the size of the ADP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.