Evidence map›Paper›PMID 17317620›Full record

ArticleMolecular cell2007

Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.

Linda K Nicholson, Kun Ping Lu

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Identification of Substrates of Cytoplasmic Peptidyl-ProlylInternational journal of molecular sciences · 2020
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. NMR reveals novel mechanisms of protein activity regulation.Protein science : a publication of the Protein Society · 2011
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Linda K NicholsonDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. lkn2@cornell.edu
Kun Ping Lu

Funding

Conformational Dynamics in Pin1 REgulation of APP Processing and Abeta ProductionR01AG029385 · NIA · CORNELL UNIVERSITY · PI NICHOLSON, LINDA K · 2007 to 2011
$2.3M
NIA NIH HHS R01 AG029385
6 · The paper itself

Abstract

In a recent issue of Molecular Cell, use NMR to identify peptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, suggesting a new mechanism for controlling the rate of formation of signaling complexes.

Indexed as

Signal TransductionIsomerismMagnetic Resonance SpectroscopyPeptidylprolyl IsomeraseProlineProtein ConformationProto-Oncogene Proteins c-crksrc Homology DomainsThermodynamicsPeptidylprolyl IsomeraseProlineProto-Oncogene Proteins c-crk

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.