Evidence map›Paper›PMID 17317388›Full record

Trial reportAmerican journal of ophthalmology2007

Impact of dry eye syndrome on vision-related quality of life.

Biljana Miljanović, Reza Dana, David A Sullivan, Debra A Schaumberg

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 350 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 7 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00678860 completednot on this mapstarted 2008, after this paper: background citation

Pilot Validation Study of Computer Administration of Vision Targeted Quality of Life Instruments

TypeobservationalSponsorNational Eye Institute (NEI)Ran2008 to 2011Enrolled147ConditionsEye Disease
NCT06220474 narecruitingnot on this mapstarted 2024, after this paper: background citation

Therapeutic Efficacy and Safety of Non-Invasive Radiofrequency Treatment in Patients With Refractory Meibomian Gland Dysfunction: A Randomized Controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2024 to 2027Enrolled112ConditionsDry Eye Syndromes, Meibomian Gland DysfunctionArmsThe Thermage FLX System, Sham treatment
3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 7 syntheses or guidelines pooled it, 826 citations in OpenAlex.

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  10. Pooled results from two pivotal randomized controlled clinical trials: ESSENCE-1 and ESSENCE-2 to assess efficacy and safety of a water-free ciclosporin 0.1% formulation for the treatment of dry eye disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Biljana MiljanovićDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Reza Dana
David A Sullivan
Debra A Schaumberg
Brigham and Women's Hospital · US

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
RISK FACTORS FOR AGE-RELATED EYE DISEASESK23EY000365 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHAUMBERG, DEBRA A · 1998 to 2000
$103k
NCI NIH HHS CA40360NCI NIH HHS CA47988NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NHLBI NIH HHS HL43851NHLBI NIH HHS R01 HL043851
6 · The paper itself

Abstract

purposeTo evaluate the impact of dry eye syndrome (DES) on vision-associated quality of life.

designCross-sectional study.

methodsWe identified 450 participants in the Women's Health Study (WHS) and 240 participants in the Physicians' Health Study (PHS) and sent a supplementary questionnaire asking how much their everyday activities were limited by symptoms of dry eye and to what degree problems with their eyes limited them in reading, driving, working at the computer, their professional activity, and watching television. By design, one-third of study subjects had clinically diagnosed DES or severe symptoms and two-thirds did not. We used logistic regression to examine relationships of DES with reported problems with everyday activities in each cohort and pooled estimates using meta-analysis methods.

resultsOf the participants invited, 85% completed the supplementary questionnaire, including 135 WHS and 55 PHS participants with DES, and 250 WHS and 149 PHS participants without DES. Controlling for age, diabetes, hypertension, and other factors, those with DES were more likely to report problems with reading ([odds ratio] OR = 3.64, 95% [confidence interval] CI 2.45 to 5.40, P < .0001); carrying out professional work (OR = 3.49, 95% CI 1.72 to 7.09, P= 0.001); using a computer (OR = 3.37, 95% CI 2.11 to 5.38, P < .0001); watching television (OR = 2.84, 95% CI 1.05 to 7.74, P = .04); driving during the day (OR = 2.80, 95% CI 1.58 to 4.96, P < .0001); and driving at night (OR = 2.20, 95% CI 1.48 to 3.28, P < .0001).

conclusionsDES is associated with a measurable adverse impact on several common and important tasks of daily living, further implicating this condition as an important public health problem deserving increased attention and resources.

Indexed as

Disability EvaluationQuality of LifeActivities of Daily LivingAdultAgedAged, 80 and overCross-Sectional StudiesDouble-Blind MethodDry Eye SyndromesFemaleHealth PersonnelHumansMiddle AgedOdds RatioSickness Impact ProfileSurveys and Questionnaires

Identifiers

PMID17317388
PMCPMC1847608
OpenAlexW2070610048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.