ReviewThe international journal of biochemistry & cell biology2007
Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency.
Review in The international journal of biochemistry & cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.Journal of cell science · 2025Article
- Review
- Imaginal Disc Regeneration: Something Old, Something New.Cold Spring Harbor perspectives in biology · 2022Review
- Recapitulation of the embryonic transcriptional program in holometabolous insect pupae.Scientific reports · 2022Article
- A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.PLoS genetics · 2021Article
- Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development.Frontiers in cell and developmental biology · 2021Article
- Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different.Open biology · 2018Review
- Cell fate changes induced by a Distal-less enhancer-trap transgene in the Drosophila antennal imaginal disc.Scientific reports · 2018Article
- Article
- The legacy of Drosophila imaginal discs.Chromosoma · 2016Review
- Maintenance of Tissue Pluripotency by Epigenetic Factors Acting at Multiple Levels.PLoS genetics · 2016Article
- A brief history of epigenetics.Cold Spring Harbor perspectives in biology · 2014Article
- Transcriptome characterization via 454 pyrosequencing of the annelid Pristina leidyi, an emerging model for studying the evolution of regeneration.BMC genomics · 2012Article
- Drosophila twin spot clones reveal cell division dynamics in regenerating imaginal discs.Developmental biology · 2011Article
- The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.Development (Cambridge, England) · 2011Article
- Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation.Molecular endocrinology (Baltimore, Md.) · 2010Review
- A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling.Nature genetics · 2009Article
- Genetic DISC-section of regeneration in Drosophila.Developmental cell · 2009Article
- Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes.Developmental cell · 2009Article
- Larval leg integrity is maintained by Distal-less and is required for proper timing of metamorphosis in the flour beetle, Tribolium castaneum.Developmental biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Drosophila imaginal discs, the primordia of the adult fly appendages, are an excellent system for studying developmental plasticity. Cells in the imaginal discs are determined for their disc-specific fate (wingness, legness) during embryogenesis. Disc cells maintain their determination during larval development, a time of extensive growth and proliferation. Only when prompted to regenerate do disc cells exhibit lability in their determined identity. Regeneration in the disc is mediated by a localized region of cell division, known as the regeneration blastema. Most regenerating disc cells strictly adhere to their disc-specific identity; some cells however, switch fate in a phenomenon known as transdetermination. Similar regeneration and transdetermination events can be induced in situ by misexpression of the signaling molecule wingless. Recent studies indicate that the plasticity of disc cells during regeneration is associated with high morphogen activity and the reorganization of chromatin structure. Here we provide both a historical perspective of imaginal disc transdetermination, as well as discuss recent findings on how imaginal disc cells acquire developmental plasticity and multipotency. We also highlight how an understanding of imaginal disc transdetermination can enhance an understanding of developmental potency exhibited by stem cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.