ArticleThe American journal of pathology1992
Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells.
Article in The American journal of pathology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 336 citations in OpenAlex.
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- Apocynin and Hyperbaric Oxygen Therapy Improve Renal Function and Structure in an Animal Model of CKD.Biomedicines · 2024Article
- Endothelin-targeted new treatments for proteinuric and inflammatory glomerular diseases: focus on the added value to anti-renin-angiotensin system inhibition.Pediatric nephrology (Berlin, Germany) · 2021Review
- Amphiregulin Aggravates GlomerulonephritisJournal of the American Society of Nephrology : JASN · 2020Article
- Range of adiposity and cardiorenal syndrome.World journal of diabetes · 2020Review
- SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis.Frontiers in cellular and infection microbiology · 2020Article
- Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy.Molecular and cellular biochemistry · 2019Article
- Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the 'resistant' C57Bl/6J mouse strain.Scientific reports · 2018Article
- IL-17C/IL-17 Receptor E Signaling in CD4Journal of the American Society of Nephrology : JASN · 2018Article
- IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases.Journal of the American Society of Nephrology : JASN · 2016Article
- Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator.EBioMedicine · 2016Article
- Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.Journal of the American Society of Nephrology : JASN · 2016Article
- Involvement of the renin-angiotensin system in the development of nephrogenic systemic fibrosis-like lesions in the RenTag mouse model.Clinical and experimental nephrology · 2016Article
- Lignans from the bark of Eucommia ulmoides inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells.Chinese medicine · 2014Article
- Advanced glycated end-products affect HIF-transcriptional activity in renal cells.Molecular endocrinology (Baltimore, Md.) · 2013Article
- AMPK mediates the initiation of kidney disease induced by a high-fat diet.Journal of the American Society of Nephrology : JASN · 2011Article
- Role of the USF1 transcription factor in diabetic kidney disease.American journal of physiology. Renal physiology · 2011Article
- Article
- Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells.Journal of the American Society of Nephrology : JASN · 2011Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A murine mesangial cell line (MMC) was established from the glomeruli of SJL mice to study the influence of angiotensin II (ANG II) on their growth and function in a serum-free culture. Murine mesangial cells exhibit the phenotypic characteristics of mesangial cells, including staining for desmin, vimentin, Thy 1, and types I and IV collagen by immunofluorescence. The addition of daily doses of 10(-6) to 10(-11) mol/l ANG II to MMCs also induced their proliferation in serum-free media. This effect on growth was independent of the presence of insulin in the media, and was receptor mediated, because the specific ANG II-receptor antagonist DuP 753 abolished proliferative growth. Angiotensin II also stimulated mainly the biosynthesis of type I collagen in our MMCs. Transfection of MMCs with chimeric genes containing enhancer/promoter elements for alpha 2(I) and alpha 1(IV) collagens linked to a chloramphenicol acetyltransferase reporter demonstrated that the stimulatory effect of ANG II for type I depends, at least to some extent, on an increase in transcription. These findings indicate collectively that ANG II in serum-free cultures can be a paracrine catalyst for the growth and biosynthesis of type I collagen in mesangial cells.
Indexed as
Identifiers
1731533PMC1886250W203342931What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.