ArticleGenes and immunity2007
Identification of bidirectional promoters in the human KIR genes.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Identification of elements determiningiScience · 2026Article
- Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements.European journal of immunology · 2026Article
- The KIR2DL1 intermediate upstream element participates in gene activation.Immunogenetics · 2023Article
- Ascorbic Acid PromotesJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Functional characterization of an inducible bidirectional promoter from Fusarium oxysporum f. sp. cubense.Scientific reports · 2020Article
- The Genetic Mechanisms Driving Diversification of theFrontiers in immunology · 2020Review
- Deciphering Natural Killer Cell Homeostasis.Frontiers in immunology · 2020Review
- Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression.Frontiers in immunology · 2018Article
- Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.Immunology · 2017Review
- Natural Killer Cells--An Epigenetic Perspective of Development and Regulation.International journal of molecular sciences · 2016Review
- Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions.Genes and immunity · 2015Article
- Characterization of a weakly expressed KIR2DL1 variant reveals a novel upstream promoter that controls KIR expression.Genes and immunity · 2014Article
- Probabilistic bidirectional promoter switches: noncoding RNA takes control.Molecular therapy. Nucleic acids · 2014Article
- The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT).Immunological reviews · 2014Review
- Identification of a KIR antisense lncRNA expressed by progenitor cells.Genes and immunity · 2013Article
- Natural killer cell biology: an update and future directions.The Journal of allergy and clinical immunology · 2013Review
- IL-2/IL-15 activate the human clonally restricted KIR3DL1 reverse promoter.Genes and immunity · 2013Article
- The yin-yang of KIR3DL1/S1: molecular mechanisms and cellular function.Critical reviews in immunology · 2013Review
- KIR2DS2 and KIR2DS4 promoter hypomethylation patterns in patients undergoing hematopoietic cell transplantation (HCT).Human immunology · 2012Article
- Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Although the class I MHC receptors expressed by human and mouse natural killer (NK) cells have distinct molecular origins, they are functional analogues that are expressed in a variegated pattern. The murine Ly49 class I receptors contain bidirectional promoters that have been proposed to control the probabilistic expression of these genes. Whether similar elements are present in the human killer Ig-like receptor (KIR) genes is a fundamental question. A detailed analysis of the 2 kb intergenic region separating the KIR2DL4 gene and the adjacent KIR3DL1 gene revealed that additional promoter elements exist in the human KIR genes. Remarkably, the previously characterized KIR3DL1 proximal promoter possesses bidirectional promoter activity that maps to an 88 bp DNA fragment containing CREB, AML, Sp1 and Ets transcription factor binding sites. Individual KIR genes and alleles possess bidirectional promoters with distinct properties. Analysis of KIR(+)and KIR(-) NK cells and NK precursors indicates that reverse transcripts from the bidirectional promoter are found in cells that lack KIR protein expression, but are not present in mature KIR-expressing NK cells, suggesting that reverse transcription from the proximal promoter blocks gene activation in immature NK and precursor cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.