ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2007
Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02777372 (Psychophysiology, Neurosteroids, and Stress in Premenstrual Dysphoric Disorder), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychophysiology, Neurosteroids, and Stress in Premenstrual Dysphoric Disorder
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of premenstrual dysphoric disorder among adolescents in Ethiopia: a systematic review and meta-analysis.Irish journal of medical science · 2021Pooled it
- Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder.BMC women's health · 2022Trial
- The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.Translational psychiatry · 2017Trial
- Affective Sensitivity to Ovarian Steroid Hormone Flux Across the Menstrual Cycle: Manifestations and Biopsychosocial Risk Factors.Annual review of clinical psychology · 2026Review
- Cortisol and ACTH response to Dex/CRH testing and 24-hour urine free cortisol levels in women with and without premenstrual dysphoric disorder.Psychoneuroendocrinology · 2025Article
- Dimensional Affective Sensitivity to Hormones across the Menstrual Cycle (DASH-MC): A transdiagnostic framework for ovarian steroid influences on psychopathology.Molecular psychiatry · 2025Review
- Enduring impact of childhood adversity: Affective modulation of acoustic startle response during pregnancy and postpartum.Physiology & behavior · 2023Article
- What Pre-clinical Rat Models Can Tell Us About Anxiety Across the Menstrual Cycle in Healthy and Clinically Anxious Humans.Current psychiatry reports · 2022Review
- Birth, love, and fear: Physiological networks from pregnancy to parenthood.Comprehensive psychoneuroendocrinology · 2022Review
- Estradiol, stress reactivity, and daily affective experiences in trauma-exposed women.Psychological trauma : theory, research, practice and policy · 2022Article
- Article
- Response to sertraline is associated with reduction in anxiety-potentiated startle in premenstrual dysphoric disorder.Psychopharmacology · 2021Article
- Estradiol and Women's Health: Considering the Role of Estradiol as a Marker in Behavioral Medicine.International journal of behavioral medicine · 2020Review
- Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle.Neurobiology of stress · 2020Article
- Suicide Risk and the Menstrual Cycle: a Review of Candidate RDoC Mechanisms.Current psychiatry reports · 2018Review
- Startling Differences: Using the Acoustic Startle Response to Study Sex Differences and Neurosteroids in Affective Disorders.Current psychiatry reports · 2018Review
- Sex as a Biological Variable: Who, What, When, Why, and How.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Stress reactivity and emotion in premenstrual syndrome.Neuropsychiatric disease and treatment · 2017Article
- Premenstrual Dysphoric Disorder: Epidemiology and Treatment.Current psychiatry reports · 2015Review
- Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder.Current psychiatry reports · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Alterations in central nervous system response to menstrual cycle-related fluctuations in neuroactive steroids are thought to underlie the emergence of negative affect in the luteal phase of the menstrual cycle in women with premenstrual dysphoric disorder (PMDD). Such changes in the neuroendocrine milieu may lead to heightened arousal and response to stress in women with PMDD. Using the acoustic startle paradigm, we sought to determine whether women with PMDD have an accentuated physiologic response to a mildly aversive stimulus during the luteal compared to follicular phase. Further, we also examined the impact of visual affective stimuli on acoustic startle response (ASR) magnitude. During the follicular and luteal phases of the menstrual cycle, acoustic stimuli (103 dB) were delivered to 15 women with PMDD and 14 healthy menstruating women of similar age. After obtaining baseline ASR, the procedure was repeated when subjects viewed pleasant, neutral and unpleasant pictures. There was a significant group by menstrual cycle phase interaction for baseline ASR magnitude, which can be attributed to the heightened startle magnitude in women with PMDD compared to healthy women during the luteal relative to the follicular phase. The direction and degree to which picture viewing modulated the startle magnitude did not vary by group or menstrual cycle phase. These data suggest that menstrual cycle phase has a powerful modulatory effect on physiologic reactivity in women with PMDD but not in healthy women. Physiologic response to affective stimuli appears to be intact in women with PMDD across the menstrual cycle.
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Registered trials
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