ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
A developmental switch to GABAergic inhibition dependent on increases in Kv1-type K+ currents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Avian cochlear nucleus neurons exhibit tonotopic specializations across development.Journal of neurophysiology · 2026Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Distinct ACC Neural Mechanisms Underlie Authentic and Transmitted Anxiety Induced by Maternal Separation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability.British journal of pharmacology · 2022Article
- Tonotopic Specializations in Number, Size, and Reversal Potential of GABAergic Inputs Fine-Tune Temporal Coding at Avian Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Intrinsic physiology of inhibitory neurons changes over auditory development.Journal of neurophysiology · 2018Article
- Need for Speed and Precision: Structural and Functional Specialization in the Cochlear Nucleus of the Avian Auditory System.Journal of experimental neuroscience · 2018Review
- Ion channel mechanisms underlying frequency-firing patterns of the avian nucleus magnocellularis: A computational model.Channels (Austin, Tex.) · 2017Article
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis.Frontiers in cellular neuroscience · 2016Article
- Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.Frontiers in neural circuits · 2014Article
- A mechanistic understanding of the role of feedforward inhibition in the mammalian sound localization circuitry.Neuron · 2013Article
- Adaptation of spike timing precision controls the sensitivity to interaural time difference in the avian auditory brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Effective sensory modality activating an escape triggering neuron switches during early development in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Analysis of GABA-induced inhibition of spontaneous firing in chick accessory lobe neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Inhibition in the balance: binaurally coupled inhibitory feedback in sound localization circuitry.Journal of neurophysiology · 2011Review
- GABAergic and glycinergic inhibition modulate monaural auditory response properties in the avian superior olivary nucleus.Journal of neurophysiology · 2011Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mature nucleus magnocellularis (NM) neurons, the avian homolog of bushy cells of the mammalian anteroventral cochlear nucleus, maintain high [Cl-]i and depolarize in response to GABA. Depolarizing GABAergic postsynaptic potentials (GPSPs) activate both the synaptic conductance and large outward currents, which, when coupled together, inhibit spikes via shunting and spike threshold accommodation. We studied the maturation of the synaptic and voltage-dependent components of inhibition in embryonic NM neurons using whole-cell and gramicidin-perforated patch-clamp techniques to measure Cl- reversal potential, GABAergic synaptic responses, and voltage-dependent outward currents. We found that GABA enhanced excitability in immature NM neurons, undergoing a switch to inhibitory between embryonic day 14 (E14) and E18. Low-voltage-activated Kv1-type (dendrotoxin-I sensitive) K+ currents increased in amplitude between E14 and E18, whereas Cl- reversal potential and synaptic conductances remained relatively stable during this period. GABA was rendered inhibitory because of this increase in low-voltage activated outward currents. GPSPs summed with other inputs to increase spike probability at E14. GPSPs shunted spikes at E18, but blocking Kv1 channels transformed this inhibition to excitation, similar to E14 neurons. Subthreshold depolarizing current steps, designed to activate outward currents similar to depolarizing GPSPs, enhanced excitability at E14 but inhibited spiking in E18 neurons. Blocking Kv1 channels reversed this effect, rendering current steps excitatory. We present the novel finding that the developmental transition of GABAergic processing from increasing neuronal excitability to inhibiting spiking can depend on changes in the expression of voltage-gated channels rather than on a change in Cl- reversal potential.
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