ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed.
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- Comprehensive mapping of Neurofibromin (NF1) expression in developing mouse brain.bioRxiv : the preprint server for biology · 2026Article
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
- Sister external tufted cells form dynamic intraglomerular ensembles representing odor identity and concentration.iScience · 2025Article
- Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Amplification of olfactory transduction currents implements sparse stimulus encoding.bioRxiv : the preprint server for biology · 2024Article
- Dense and Persistent Odor Representations in the Olfactory Bulb of Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Firing Patterns of Mitral Cells and Their Transformation in the Main Olfactory Bulb.Brain sciences · 2024Article
- Biosensors for Odor Detection: A Review.Biosensors · 2023Review
- Olfactory response is a potential sign of consciousness: electroencephalogram findings.Frontiers in neuroscience · 2023Article
- Stability and flexibility of odor representations in the mouse olfactory bulb.Frontiers in neural circuits · 2023Article
- Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia.IBRO neuroscience reports · 2022Article
- Article
- Biological constraints on configural odour mixture perception.The Journal of experimental biology · 2022Article
- Paradoxical relationship between speed and accuracy in olfactory figure-background segregation.PLoS computational biology · 2021Article
- Encoding innately recognized odors via a generalized population code.Current biology : CB · 2021Article
- Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior.PloS one · 2021Article
- Effect of Interglomerular Inhibitory Networks on Olfactory Bulb Odor Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
35 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
The mammalian olfactory system recognizes an enormous variety of odorants carrying a wide range of important behavioral cues. In the main olfactory bulb (MOB), odorants are ultimately represented through the action potential activity of mitral/tufted cells (M/Ts), whose selectivity and tuning to odorant molecules are therefore fundamental determinants of MOB sensory coding. However, the sheer number and diversity of discrete olfactory stimuli has been a major barrier to comprehensively evaluating M/T selectivity. To address this issue, we assessed M/T odorant responses in anesthetized mice to a 348-odorant panel widely and systematically distributed throughout chemical space, presented both individually and in mixtures at behaviorally relevant concentrations. We found that M/T activation by odorants was markedly selective, with neurons responding robustly, sensitively, and reliably to only a highly restricted subset of stimuli. Multiple odorants activating a single neuron commonly shared clear structural similarity, but M/T tuning also frequently extended beyond obviously defined chemical categories. Cells typically responded to effective compounds presented both individually and in mixtures, although firing rates evoked by mixtures typically showed partial suppression. Response selectivity was further confirmed in awake animals by chronic recordings of M/Ts. These data indicate that individual M/Ts encode specific odorant attributes shared by only a small fraction of compounds and imply that the MOB relays the collective molecular features of an odorant stimulus through a restricted set of M/Ts, each narrowly tuned to a particular stimulus characteristic.
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