ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 127 citations in OpenAlex.
- Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface.Frontiers in cell and developmental biology · 2025Article
- Indirect neurogenesis in space and time.Nature reviews. Neuroscience · 2024Review
- Article
- Neurogenic Stem Cell Niche in the Auditory Thalamus: In Vitro Evidence of Neural Stem Cells in the Rat Medial Geniculate Body.Life (Basel, Switzerland) · 2023Article
- FGF-MAPK signaling regulates human deep-layer corticogenesis.Stem cell reports · 2021Article
- Different Neurogenic Potential in the Subnuclei of the Postnatal Rat Cochlear Nucleus.Stem cells international · 2021Article
- Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration.International journal of molecular sciences · 2020Article
- Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.Human molecular genetics · 2020Article
- FGF2: a novel druggable target for glioblastoma?Expert opinion on therapeutic targets · 2020Review
- Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus.Stem cells international · 2019Article
- Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma.BMC cancer · 2018Article
- GDNF/GFRα1 Complex Abrogates Self-Renewing Activity of Cortical Neural Precursors Inducing Their Differentiation.Stem cell reports · 2018Article
- Neural precursor cells form integrated brain-like tissue when implanted into rat cerebrospinal fluid.Communications biology · 2018Article
- Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme.Oxidative medicine and cellular longevity · 2018Article
- Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1.Cerebellum (London, England) · 2017Article
- Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage.Cell reports · 2017Article
- The Multiple Roles of FGF Signaling in the Developing Spinal Cord.Frontiers in cell and developmental biology · 2017Review
- Resin embedded multicycle imaging (REMI): a tool to evaluate protein domains.Scientific reports · 2016Article
- Mimicking Neural Stem Cell Niche by Biocompatible Substrates.Stem cells international · 2016Review
- Pluripotency Genes and Their Functions in the Normal and Aberrant Breast and Brain.International journal of molecular sciences · 2015Review
4 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 2 countries.
Funding
Abstract
Developmental processes mediating the initiation of lineage commitment from self-renewing neural stem cells (NSCs) remain mostly unclear because of the persisting ambiguity in identifying true NSCs from proliferative lineage-restricted progenitors (LRPs), which are directly or indirectly derived from NSCs. Our multilineage immunohistochemical analyses of early embryonic rat telencephalon at the onset of neurogenesis revealed clear dorsoventral gradients in the emergence of two types of neuronal progenitors (NPs) from multilineage-negative NSCs. Enumeration of NSCs using comprehensive flow cytometric analysis demonstrated that their precipitous decline in vivo involved both active differentiation into NPs and an increased propensity toward apoptosis. Both processes paralleled the dorsoventral changes in fibroblast growth factor receptor (FGFR) expressions. NSCs residing in the dorsal telencephalon coexpressed FGFR1 and FGFR3, whereas those residing in the ventral telencephalon also expressed FGFR2. NSCs exposed to basic fibroblast growth factor (bFGF) in vitro generated four stereotypical clonal expansion states: efficiently self-renewing, inefficiently self-renewing limited by apoptosis, exclusively neurogenic, and multipotential, generating up to five types of LRPs. The plasticity among these expansion states depended on ambient [bFGF], telencephalic developmental stage, and differential activation/inactivation of specific FGFRs. Coactivation of FGFR1 and FGFR3 promoted symmetrical divisions of NSCs (self-renewal), whereas inactivation of either triggered asymmetrical divisions and neurogenesis from these cells. Developmental upregulation of FGFR2 expression correlated with a shift of NSCs into a multipotential state or apoptosis. These results provide new insights regarding the roles of FGFRs in diversification of NSC properties and initiation of neural lineage-restricted differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.