ArticleImmunology2007
CD4+ CD8+ T cells in young and elderly humans. Comment on Macchia I, Gauduin MC, Kaur A, Johnson RP. Expression of CD8alpha identifies a distinct subset of effector memory CD4 T lymphocytes. Immunology 2006; 119:232-42.
Article in Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 10 citations in OpenAlex.
- Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors.Immunity & ageing : I & A · 2009Article
Corrections and comments
- Comment on
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral CD4(+) CD8(+) T cells have been described in animals as well as in humans. Two distinct populations can be distinguished, namely CD4(lo) CD8(hi) and CD4(hi) CD8(lo) T cells. We demonstrate here that the increase in the number of peripheral CD4(+) CD8(+) T cells in the elderly is the result of an increase of the CD4(lo) CD8(hi) T-cell population. While the phenotype of CD4(lo) CD8(hi) and CD4(hi) CD8(lo) T cells was very similar in young persons, CD4(hi) CD8(lo), T cells from elderly subjects expressed a more differentiated phenotype and produced less interleukin-2 compared to CD4(lo) CD8(hi) T cells. In conclusion, our results suggest that aging leads to a phenotypic and functional difference between CD4(+) CD8(+) T-cell subsets. It may therefore be of relevance to distinguish between these subsets before assessing their functional significance in elderly humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.