ArticleProceedings of the National Academy of Sciences of the United States of America1992
Testis-/embryo-expressed genes are clustered in the mouse H-2K region.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 44 citations in OpenAlex.
- Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility.Basic and clinical andrology · 2021Review
- Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Gene conversion of major histocompatibility complex genes in the mouse spermatogenesis is a premeiotic event.Molecular biology of the cell · 1997Article
- Characterization of a minus end-directed kinesin-like motor protein from cultured mammalian cells.The Journal of cell biology · 1995Article
- Physical mapping of the retinoid X receptor B gene in mouse and human.Immunogenetics · 1995Article
- The human BAT3 ortholog in rodents is predominantly and developmentally expressed in testis.Molecular and cellular biochemistry · 1994Article
- Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region.Immunogenetics · 1994Article
- Transcriptional organization of a 450-kb region of the human X chromosome in Xq28.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Rapid isolation of desired sequences from lone linker PCR amplified cDNA mixtures: application to identification and recovery of expressed sequences in cloned genomic DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The major histocompatibility complex (MHC) of the mouse is located on chromosome 17 in the distal inversion of the t complex. In addition to genes playing major roles in the immune response, it contains a diversity of genes. In humans, numerous diseases are known to be associated with the MHC loci. Moreover, at least three recessive embryonic t-lethal mutations have been mapped to the MHC. Here a molecular genetic approach was used to study the detailed genomic structure of 240 kilobases (kb) surrounding the H-2K gene and 150 kb of a partly homologous region located in the distal inversion of the t complex. Combined with previous findings, the H-2K region was found to contain an impressively high density of genes--12 transcription units in 240 kb. Surprisingly, virtually all of these genes are expressed in testis and/or embryos. The genomic organization of this region is contrasted with the 150 kb of the homologous area where only three genes and an endogenous retrovirus reside.
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