ArticleProceedings of the National Academy of Sciences of the United States of America1992
Molecular structure of the human desmoplakin I and II amino terminus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 96 citations in OpenAlex.
- Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum.PloS one · 2023Article
- Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo.Developmental biology · 2019Article
- SUMOylation of periplakin is critical for efficient reorganization of keratin filament network.Molecular biology of the cell · 2019Article
- Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.Journal of molecular biology · 2011Article
- Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associated mutations from background genetic noise.Journal of the American College of Cardiology · 2011Article
- The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat.The Journal of biological chemistry · 2011Article
- Identification and characterization of DSPIa, a novel isoform of human desmoplakin.Cell and tissue research · 2010Article
- Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities.The Journal of investigative dermatology · 2010Article
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily.Journal of molecular biology · 2007Article
- Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules.Molecular biology of the cell · 2006Article
- Genetic bases of arrhythmogenic right ventricular Cardiomyopathy.Heart international · 2006Article
- Genetic alterations at the Bpag1 locus in dt mice and their impact on transcript expression.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Epidermal growth factor suppresses induction by progestin of the adhesion protein desmoplakin in T47D breast cancer cells.Breast cancer research : BCR · 2004Article
- Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.American journal of human genetics · 2002Article
- Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31.Journal of virology · 2000Article
- Defining the interactions between intermediate filaments and desmosomes.The Journal of cell biology · 1998Article
- Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin.The Journal of cell biology · 1997Article
- The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.The Journal of cell biology · 1997Article
- Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin.The Journal of cell biology · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Desmoplakins (DPs) I and II are closely related proteins found in the innermost region of the desmosomal plaque, which serves as a cell surface attachment site for cytoplasmic intermediate filaments. Overlapping cDNA clones comprising 9.2 kilobases of DP-I, predicted to encode a full-length 310-kDa polypeptide (2677 amino acid residues), have now been identified. Here we report the predicted protein sequence and structural analysis of the N terminus of DP, extending our previous study of the rod and carboxyl domains. The N terminus contains groups of heptad repeats that are predicted to form at least two major alpha-helical-rich bundles. Unlike the rod and carboxyl domains, the N terminus did not display a periodic distribution of charged residues. Northern blot mapping and genomic sequence analysis were also undertaken to examine the organization of the DP mRNAs. A 1-kilobase intron was located at the 3' boundary of a DP-I-specific region; however, instead of an intron at the 5' junction, a possible splice donor site was observed within a potential coding sequence, suggesting alternative RNA splicing from an internal donor site.
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