ReviewThe Journal of cell biology2007
Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria.
Review in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Polysulfides promote protein disulfide bond formation in microorganisms growing under anaerobic conditions.Applied and environmental microbiology · 2025Article
- Papain expression in theApplied and environmental microbiology · 2025Article
- Expression of Cytochrome c3 fromInternational journal of molecular sciences · 2021Article
- Regulation of the redox metabolome and thiol proteome by hydrogen sulfide.Critical reviews in biochemistry and molecular biology · 2021Article
- Effects of Liposome and Cardiolipin on Folding and Function of Mitochondrial Erv1.International journal of molecular sciences · 2020Article
- Redox characterisation of Erv1, a key component for protein import and folding in yeast mitochondria.The FEBS journal · 2020Article
- Production of Extracellular Matrix Proteins in the Cytoplasm ofInternational journal of molecular sciences · 2020Article
- The role of thiols in antioxidant systems.Free radical biology & medicine · 2019Review
- Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.Chemical reviews · 2018Review
- Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function.Journal of virology · 2017Article
- Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity.Archives of biochemistry and biophysics · 2015Article
- Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy.Neurogenetics · 2015Article
- Oxidative folding in the mitochondrial intermembrane space in human health and disease.International journal of molecular sciences · 2013Article
- Nanomaterials and nanotechnology for skin tissue engineering.International journal of burns and trauma · 2012Article
- Identification of a redox-modulatory interaction between uncoupling protein 3 and thioredoxin 2 in the mitochondrial intermembrane space.Antioxidants & redox signaling · 2011Article
- Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective.The Journal of biological chemistry · 2011Article
- Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I.The Biochemical journal · 2011Article
- A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy.American journal of human genetics · 2011Article
- Common ground for protein translocation: access control for mitochondria and chloroplasts.Nature reviews. Molecular cell biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intermembrane space (IMS) of mitochondria, the compartment that phylogenetically originated from the periplasm of bacteria, contains machinery to catalyze the oxidative folding of proteins (Mesecke, N., N. Terziyska, C. Kozany, F. Baumann, W. Neupert, K. Hell, and J.M. Herrmann. 2005. Cell. 121:1059-1069; Rissler, M., N. Wiedemann, S. Pfannschmidt, K. Gabriel, B. Guiard, N. Pfanner, and A. Chacinska. 2005. J. Mol. Biol. 353: 485-492; Tokatlidis, K. 2005. Cell. 121:965-96). This machinery introduces disulfide bonds into newly imported precursor proteins, thereby locking them in a folded conformation. Because folded proteins cannot traverse the translocase of the outer membrane, this stably traps the proteins in the mitochondria. The principle of protein oxidation in the IMS presumably has been conserved from the bacterial periplasm and has been adapted during evolution to drive the vectorial translocation of proteins from the cytosol into the mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.