ArticleThorax2007
The growing impact of HIV infection on the epidemiology of tuberculosis in England and Wales: 1999 2003.
Article in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Article
- The resurgence of tuberculosis and the implications for primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2013Article
- Article
- DOT associated with reduced all-cause mortality among tuberculosis patients in Taipei, Taiwan, 2006-2008.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2012Article
- HIV and tuberculosis: a deadly human syndemic.Clinical microbiology reviews · 2011Review
- Factors associated with tuberculosis as an AIDS-defining disease in an immigration setting.Journal of epidemiology · 2011Article
- Clinical presentation, demographics and outcome of tuberculosis (TB) in a low incidence area: a 4-year study in Geneva, Switzerland.BMC infectious diseases · 2009Article
- A trend analysis and sub-regional distribution in number of people living with HIV and dying with TB in Africa, 1991 to 2006.International journal of health geographics · 2009Article
- Epidemiology of HIV-associated tuberculosis.Current opinion in HIV and AIDS · 2009Review
- Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil.American journal of epidemiology · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have estimated the prevalence of tuberculosis and HIV infection in population subgroups in the UK. This study was undertaken to describe recent trends in the proportion of individuals with HIV infection among reported cases of tuberculosis in England and Wales, and to review the implications for clinical and public health care.
methodsA population-based matching study using national surveillance databases was used to investigate all persons aged 15 years and over reported with a diagnosis of tuberculosis to the Health Protection Agency in England and Wales in 1999-2003. Record linkage was used to match the national tuberculosis and HIV/AIDS surveillance databases to identify all cases of tuberculosis and determine the proportion of patients with tuberculosis co-infected with HIV. The distribution and characteristics of the cases were determined and the trend examined by year.
resultsOf 30,670 cases of tuberculosis reported in England and Wales between 1999 and 2003, an estimated 1743 (5.7%) were co-infected with HIV. There was a year on year increase in the proportion from 3.1% (169/5388) in 1999 to 8.3% (548/6584) in 2003 (p for trend <0.0001). Co-infected patients contributed to almost a third of the increase in the number of cases of tuberculosis during the 5 year period. Patients co-infected with HIV were predominantly those born abroad. 18.5% (n = 323) of co-infected patients had not been reported as active cases of tuberculosis on the national tuberculosis database.
conclusionThe proportion of patients with tuberculosis co-infected with HIV in England and Wales is increasing, with the greatest impact on those born abroad regardless of their ethnic origin. With HIV infection contributing substantially to the increase in the number of cases of tuberculosis, close cooperation in the clinical management and accurate notification of patients is vital if appropriate care and public health action is to be achieved.
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