ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Temporal and epigenetic regulation of neurodevelopmental plasticity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Blood Serum From Obese Women Raises ROS Production by Neural Stem Cells.Developmental neurobiology · 2026Article
- Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders.Neuronal signaling · 2023Review
- Genetics of language and its implications on language interventions.Journal of genetics · 2018Review
- Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia.Scientific reports · 2018Article
- Gray matter volumetric abnormalities associated with the onset of psychosis.Frontiers in psychiatry · 2012Article
- The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Dynamic methylation and expression of Oct4 in early neural stem cells.Journal of anatomy · 2010Article
- Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Cellular epigenetic modifications of neural stem cell differentiation.Cell transplantation · 2009Article
- Introduction: stem cells and brain repair.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The anticipated therapeutic uses of neural stem cells depend on their ability to retain a certain level of developmental plasticity. In particular, cells must respond to developmental manipulations designed to specify precise neural fates. Studies in vivo and in vitro have shown that the developmental potential of neural progenitor cells changes and becomes progressively restricted with time. For in vitro cultured neural progenitors, it is those derived from embryonic stem cells that exhibit the greatest developmental potential. It is clear that both extrinsic and intrinsic mechanisms determine the developmental potential of neural progenitors and that epigenetic, or chromatin structural, changes regulate and coordinate hierarchical changes in fate-determining gene expression. Here, we review the temporal changes in developmental plasticity of neural progenitor cells and discuss the epigenetic mechanisms that underpin these changes. We propose that understanding the processes of epigenetic programming within the neural lineage is likely to lead to the development of more rationale strategies for cell reprogramming that may be used to expand the developmental potential of otherwise restricted progenitor populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.