ArticleBMC genomics2007
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 78 citations in OpenAlex.
- Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling.Cancer reports (Hoboken, N.J.) · 2026Article
- Forward-reverse mutation cycles in cancer cell lines under chemical treatments.Human genomics · 2024Article
- New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors.Molecular pharmacology · 2024Review
- Cytogenetic and Biochemical Genetic Techniques for Personalized Drug Therapy in Europe.Diagnostics (Basel, Switzerland) · 2021Review
- NFrontiers in oncology · 2021Article
- A thirteen‑gene set efficiently predicts the prognosis of glioblastoma.Molecular medicine reports · 2019Article
- hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation.BMC bioinformatics · 2018Article
- Characterization of genomic changes in the cervical pre-cancerous lesions and tumors induced by different types of human papillomaviruses.Virusdisease · 2016Article
- Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Steroid receptor coactivators as therapeutic targets in the female reproductive system.The Journal of steroid biochemistry and molecular biology · 2015Review
- Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH.International journal of clinical and experimental pathology · 2014Article
- Impact of gene dosage on gene expression, biological processes and survival in cervical cancer: a genome-wide follow-up study.PloS one · 2014Article
- Alternative polyadenylation of tumor suppressor genes in small intestinal neuroendocrine tumors.Frontiers in endocrinology · 2014Article
- A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.Molecular cell · 2013Article
- Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer.International journal of clinical and experimental pathology · 2013Article
- Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review.Molecular cytogenetics · 2012Article
- Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.PloS one · 2012Article
- Integrated genomic analysis of sézary syndrome.Genetics research international · 2011Article
- Integrative genomic approaches in cervical cancer: implications for molecular pathogenesis.Future oncology (London, England) · 2010Review
- Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours.BMC research notes · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygosity (LOH). Currently, high throughput methods such as array comparative genomic hybridization (array CGH), single nucleotide polymorphism array (SNP array) and gene expression arrays are available to study genome-wide alterations. Integration of these 3 platforms allows detection of genomic alterations at high resolution and investigation of an association between copy number changes and expression.
resultsGenome-wide copy number and genotype analysis of 10 cervical cancer cell lines by array CGH and SNP array showed highly complex large-scale alterations. A comparison between array CGH and SNP array revealed that the overall concordance in detection of the same areas with copy number alterations (CNA) was above 90%. The use of SNP arrays demonstrated that about 75% of LOH events would not have been found by methods which screen for copy number changes, such as array CGH, since these were LOH events without CNA. Regions frequently targeted by CNA, as determined by array CGH, such as amplification of 5p and 20q, and loss of 8p were confirmed by fluorescent in situ hybridization (FISH). Genome-wide, we did not find a correlation between copy-number and gene expression. At chromosome arm 5p however, 22% of the genes were significantly upregulated in cell lines with amplifications as compared to cell lines without amplifications, as measured by gene expression arrays. For 3 genes, SKP2, ANKH and TRIO, expression differences were confirmed by quantitative real-time PCR (qRT-PCR).
conclusionThis study showed that copy number data retrieved from either array CGH or SNP array are comparable and that the integration of genome-wide LOH, copy number and gene expression is useful for the identification of gene specific targets that could be relevant for the development and progression in cervical cancer.
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