ArticleJournal of medical virology2007
Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy.
Article in Journal of medical virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Molecular epidemiology of respiratory syncytial virus in children with acute respiratory illnesses in Africa: A systematic review and meta-analysis.Journal of global health · 2023Pooled it
- Spotlight influenza: Laboratory-confirmed seasonal influenza in people with acute respiratory illness: a literature review and meta-analysis, WHO European Region, 2004 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Pooled it
- Human metapneumovirus in patients hospitalized with acute respiratory infections: A meta-analysis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Pooled it
- Recommendations for treatment of childhood non-severe pneumonia.The Lancet. Infectious diseases · 2009Guideline
- Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 - 2017).PloS one · 2018Trial
- The prevalence and role of human respiratory syncytial virus in pediatric respiratory tract infections: a systematic review and meta-analysis of global data.EClinicalMedicine · 2026Article
- Semiannual seasonality of COVID-19 with alternating peaks in winter and summer.Frontiers in public health · 2026Article
- Viral Respiratory Infections in Djibouti: Insights from Two Years of Pilot Surveillance.Viruses · 2025Article
- Multicenter epidemiological investigation and genetic characterization of respiratory syncytial virus and metapneumovirus infections in the pre-pandemic 2018-2019 season in northern and central Italy.Clinical and experimental medicine · 2023Article
- PCR-based diagnosis of respiratory virus in postsurgical septic patients: A preliminary study before SARS-CoV-2 pandemic.Medicine · 2022Article
- Development of a diagnostic assay by three-tube multiplex real-time PCR for simultaneous detection of nine microorganisms causing acute respiratory infections.Scientific reports · 2022Article
- An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children.Frontiers in pediatrics · 2022Article
- Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω.Frontiers in immunology · 2022Article
- Spread of Respiratory Pathogens During the COVID-19 Pandemic Among Children in the Northeast of Italy.Frontiers in microbiology · 2022Article
- Human bocavirus-1 screening in infants with acute lower respiratory tract infection.The Journal of international medical research · 2021Article
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- The Effect ofFrontiers in pharmacology · 2021Review
- Human bocavirus in children hospitalized for acute respiratory tract infection in Rome.World journal of pediatrics : WJP · 2020Article
- Differential interferon gene expression in bronchiolitis caused by respiratory syncytial virus-A genotype ON1.Medical microbiology and immunology · 2020Article
- Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit?Frontiers in public health · 2020Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection of a broad number of respiratory viruses is not undertaken currently for the diagnosis of acute respiratory infection due to the large and always increasing list of pathogens involved. A 1-year study was undertaken on children hospitalized consecutively for acute respiratory infection in a Pediatric Department in Rome to characterize the viruses involved. Two hundred twenty-seven children were enrolled in the study with a diagnosis of asthma, bronchiolitis, bronchopneumonia, or laringo-tracheo bronchitis. A molecular approach was adopted using specific reverse transcription (RT)-PCR assays detecting 13 respiratory viruses including metapneumovirus (hMPV) and the novel coronaviruses NL63 and HKU1; most amplified fragments were sequenced to confirm positive results and differentiate the strain. Viral pathogens were detected in 97 samples (42.7%), with 4.8% of dual infections identified; respiratory syncytial virus (RSV) was detected in 17.2% of children, followed by rhinovirus (9.7%), parainfluenza virus type 3 (PIV3) (7.5%), and influenza type A (4.4%). Interestingly, more than half the patients (9/17) that have rhinovirus as the sole respiratory pathogen had pneumonia. HMPV infected children below 3 years in two peaks in March and June causing bronchiolitis and pneumonia. One case of NL63 infection is described, documenting NL63 circulation in central Italy. In conclusion, the use of a comprehensive number of PCR-based tests is recommended to define the burden of viral pathogens in patients with respiratory tract infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.