Evidence map›Paper›PMID 17311057›Full record

ArticleEuropean journal of clinical nutrition2008

Maternal vitamin D status during pregnancy and child outcomes.

C R Gale, S M Robinson, N C Harvey, M K Javaid, B Jiang, C N Martyn, K M Godfrey, C Cooper, Princess Anne Hospital Study Group

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02215213 (Assessment of Dose Effectiveness of Vitamin D Supplementation During Pregnancy), which is not on this map. Cited by 249 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 18 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02215213 nacompletednot on this mapstarted 2013, after this paper: background citation

Assessment of Dose Effectiveness of Vitamin D Supplementation During Pregnancy

TypeinterventionalSponsorAga Khan UniversityRan2013 to 2016Enrolled350ConditionsPregnancyArmsVitamin D supplement
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 18 syntheses or guidelines pooled it, 660 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Trial
  20. Trial

189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

C R GaleMRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK. drg@mrc.soton.ac.uk
S M Robinson
N C Harvey
M K Javaid
B Jiang
C N Martyn
K M Godfrey
C Cooper
Princess Anne Hospital Study Group
Southampton General Hospital · GBUniversity of Southampton · GB

Funding

Medical Research Council MC_U147574237Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council U.1475.00.003.00010.02(74237)
6 · The paper itself

Abstract

objectiveTo investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child.

designProspective study.

settingPrincess Anne Maternity Hospital, Southampton, UK. SUBJECTS: A group of 596 pregnant women were recruited. A total of 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years.

methodsMaternal 25 (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a dual energy x-ray absorptiometry scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed.

resultsThere were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15-9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09-26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol/l.

conclusionExposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.

Indexed as

Nutritional StatusAsthmaChildChild DevelopmentCohort StudiesDermatitis, AtopicFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMaternal Nutritional Physiological PhenomenaPregnancyPregnancy OutcomeProspective Studies25-hydroxyvitamin DVitamin D

Identifiers

PMID17311057
PMCPMC2629513
OpenAlexW2168383921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.