ArticleOncogene2007
Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.International journal of molecular sciences · 2022Review
- Olfactory Receptor OR7A17 Expression Correlates with All-International journal of molecular sciences · 2021Article
- Effect of cAMP Signaling Regulation in Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells.Cells · 2020Article
- ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.Oncogene · 2015Article
- On the role of skin in the regulation of local and systemic steroidogenic activities.Steroids · 2015Review
- Wnt signaling in remyelination in multiple sclerosis: friend or foe?Molecular neurobiology · 2014Review
- Id transcriptional regulators in adipogenesis and adipose tissue metabolism.Frontiers in bioscience (Landmark edition) · 2014Review
- Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity.Experimental dermatology · 2014Article
- Coordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues.Neuroscience bulletin · 2013Article
- A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells.PloS one · 2013Article
- Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.The Journal of biological chemistry · 2011Article
- Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.Molecular biology of the cell · 2010Article
- Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer.Biochimica et biophysica acta · 2009Review
- HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.Nature neuroscience · 2009Article
- Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.Molecular pharmacology · 2008Article
- Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.Oncogene · 2008Article
- Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.Development (Cambridge, England) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of all-trans-retinoic acid (atRA) on proliferation in several human skin cell lines and found that antiproliferative potency of atRA correlated with the endogenous activity of canonical Wnt signaling. In HaCaT keratinocytes, we found that atRA significantly suppressed the expression of Id2, a member of the inhibitor of differentiation family of transcription factors that regulate cell growth and differentiation. However, no apparent change in the expression of other Wnt targets, like c-Myc or cyclin D1, was observed. Retinoid-induced Id2 gene suppression was associated with decreased levels of histone H3 and H4 acetylation and histone H3 Lys-4 methylation, and with recruitment of the LSD1 demethylase at the Wnt-response element (WRE) (TCF/LEF-binding site), in the Id2 gene promoter. None of such changes was detected at the WRE of c-Myc and cyclin D1 gene promoters. Inhibition of Id2 by short interfering RNA (siRNA) had a similar effect on the proliferation of HaCaT cells as exposure to atRA, whereas anti-beta-catenin siRNA significantly inhibited its antiproliferative effect. These data suggest that downregulation of Id2 gene expression through transcriptional convergence between Wnt and retinoid signaling pathways underlies the antiproliferative effect of retinoids in keratinocytes, and provide evidence of gene-targeted crosstalk between signaling pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.