ArticleExperimental brain research2007
Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide.
Article in Experimental brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Sustained Energy Deficit Following Perinatal Asphyxia: A Shift towards the Fructose-2,6-bisphosphatase (TIGAR)-Dependent Pentose Phosphate Pathway and Postnatal Development.Antioxidants (Basel, Switzerland) · 2021Review
- Synaptoprotection in Perinatal Asphyxia: An Experimental Approach.Frontiers in synaptic neuroscience · 2020Article
- Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?Neurotoxicity research · 2018Review
- Vulnerability to a Metabolic Challenge Following Perinatal Asphyxia Evaluated by Organotypic Cultures: Neonatal Nicotinamide Treatment.Neurotoxicity research · 2017Article
- Nitric Oxide Production in the Striatum and Cerebellum of a Rat Model of Preterm Global Perinatal Asphyxia.Neurotoxicity research · 2017Article
- Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of DNeurotoxicity research · 2017Article
- Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model.Neural plasticity · 2017Review
- Perinatal asphyxia: CNS development and deficits with delayed onset.Frontiers in neuroscience · 2014Review
- Environmental enrichment decreases asphyxia-induced neurobehavioral developmental delay in neonatal rats.International journal of molecular sciences · 2013Article
- Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats.Journal of exercise rehabilitation · 2013Article
- Article
- Bacopa monnieri extract offsets rotenone-induced cytotoxicity in dopaminergic cells and oxidative impairments in mice brain.Cellular and molecular neurobiology · 2012Article
- Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes?The EPMA journal · 2011Article
- Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.Neurotoxicity research · 2011Review
- Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats.Experimental brain research · 2010Article
- MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.Metabolic brain disease · 2009Article
- Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats.Experimental brain research · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential neuroprotection of nicotinamide on the consequences of perinatal asphyxia was investigated with triple organotypic cultures. Perinatal asphyxia was induced in vivo by immersing foetuses-containing uterine horns removed from ready-to-deliver rats into a water bath for 20 min. Sibling caesarean-delivered pups were used as controls. Three days later tissue from substantia nigra, neostriatum and neocortex was dissected and placed on a coverslip. After a month, the cultures were processed for immunocytochemistry and phenotyped with markers against the NMDA receptor subunit NR1, tyrosine hydroxylase (TH), or neuronal nitric oxide synthase (nNOS). Some cultures were analysed for cell viability. Nicotinamide (0.8 mmol/kg, i.p.) or saline was administered to asphyxia-exposed and caesarean-delivered control pups 24, 48 and 72 h after birth. Perinatal asphyxia produced a decrease of cell viability in substantia nigra, but not in neostriatum or neocortex. Immunocytochemistry confirmed the vulnerability of the substantia nigra, demonstrating that there was a significant decrease in the number of NR1 and TH-positive (+) cells/mm2, as well as a decrease in the length of TH+ processes, suggesting neurite atrophy. In control cultures, many nNOS+ cells were seen, with different features, regional distribution and cell body sizes. Following perinatal asphyxia, there was an increase in the number of nNOS+ cells/mm2 in substantia nigra, versus a decrease in neostriatum including reduced neurite length, and no apparent changes in neocortex. The main effect of nicotinamide was seen in the neostriatum, preventing the asphyxia-induced decrease in the number of nNOS+ cells and neurite length. Nicotinamide also prevented the effect of perinatal asphyxia on TH-positive neurite length. The present results support the idea that nicotinamide can prevent the effects produced by a sustained energy-failure condition, as occurring during perinatal asphyxia.
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