ArticleMolecular psychiatry2007
Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022Review
- Intellectual disability: dendritic anomalies and emerging genetic perspectives.Acta neuropathologica · 2021Review
- Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth.Development and psychopathology · 2021Article
- Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation.Addiction biology · 2020Article
- A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms.Psychiatry investigation · 2018Article
- Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder.Frontiers in integrative neuroscience · 2018Article
- Inattention and Reaction Time Variability Are Linked to Ventromedial Prefrontal Volume in Adolescents.Biological psychiatry · 2017Article
- Validation of a Brief Structured Interview: The Children's Interview for Psychiatric Syndromes (ChIPS).Journal of clinical psychology in medical settings · 2016Article
- Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development.Developmental science · 2014Article
- Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in Tourette syndrome: a pilot study.BMC medical genomics · 2012Article
- An association study on the polymorphisms of dopaminergic genes with working memory in a healthy Chinese Han population.Cellular and molecular neurobiology · 2012Article
- Multivariate analysis of anxiety disorders yields further evidence of linkage to chromosomes 4q21 and 7p in panic disorder families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- Genetic variation in the KIAA0319 5' region as a possible contributor to dyslexia.Behavior genetics · 2011Article
- Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Genetics of developmental dyslexia.European child & adolescent psychiatry · 2010Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Twin studies have provided evidence for shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) and specific reading disabilities (RD), with this overlap being highest for the inattentive symptom dimension of ADHD. Previously, we found evidence for association of the dopamine receptor D1 gene (DRD1) with ADHD, and with the inattentive symptom dimension in particular. This, combined with evidence for working memory (WM) deficits in individuals with RD or ADHD, and the importance of D1 receptors in attentional processes and WM function, suggests that DRD1 may be a common genetic influence underlying both disorders. Here, in a study of 232 families ascertained through probands with reading problems, we tested for association of the DRD1 gene with RD, as a categorical trait, and with quantitative measures of key reading component skills, WM ability, and inattentive symptoms. Although no associations were found with RD, or with reading component skills or verbal WM, we found evidence for association with inattentive behaviour. Specifically, DRD1 Haplotype 3, the haplotype previously found to be associated with inattentive symptoms in ADHD, is also associated with parent- and teacher-reported symptoms of inattention in this sample selected for reading problems (P=0.023 and 0.004, respectively). Together, the replicated finding of Haplotype 3 association with inattentive symptoms in two independent study samples strongly supports a role for DRD1 in attentional ability. Furthermore, the association of DRD1 with inattention, but not with RD, or the other reading and reading-related phenotypes analysed, suggests that DRD1 contributes uniquely to inattention, without overlap for reading ability.
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Registered trials
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