ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models.Scientific reports · 2025Article
- CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells.Cell reports. Medicine · 2024Article
- Mechanistic insights into medulloblastoma relapse.Pharmacology & therapeutics · 2024Review
- Learning cell identity in immunology, neuroscience, and cancer.Seminars in immunopathology · 2023Review
- Impact of Regorafenib on Endothelial Transdifferentiation of Glioblastoma Stem-like Cells.Cancers · 2022Article
- Article
- A Detailed Overview About the Single-Cell Analyses of Solid Tumors Focusing on Colorectal Cancer.Pathology oncology research : POR · 2022Review
- Drug resistance and Cancer stem cells.Cell communication and signaling : CCS · 2021Review
- Gliomasphere marker combinatorics: multidimensional flow cytometry detects CD44+/CD133+/ITGA6+/CD36+ signature.Journal of cellular and molecular medicine · 2019Article
- Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.Scientific reports · 2018Article
- Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats.Molecular neurobiology · 2018Article
- Limbic Tumors of the Temporal Lobe: Radiologic-Pathologic Correlation.Clinical neuroradiology · 2015Article
- Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.Cell death & disease · 2014Article
- Glucose-6-phosphatase is a key metabolic regulator of glioblastoma invasion.Molecular cancer research : MCR · 2014Article
- Article
- iNOS: a potential therapeutic target for malignant glioma.Current molecular medicine · 2013Review
- Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall.Cancer cell international · 2012Article
- Convergence of normal stem cell and cancer stem cell developmental stage: Implication for differential therapies.World journal of stem cells · 2011Article
- Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.Journal of neuro-oncology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conceptual and technical advances in neural stem cell biology are being applied to the study of human brain tumours. These studies suggest that human brain tumours are organized as a hierarchy and are maintained by a small number of tumour cells that have stem cell properties. Most of the bulk population of human brain tumours comprise cells that have lost the ability to initiate and maintain tumour growth. Although the cell of origin for human brain tumours is uncertain, recent evidence points towards the brain's known proliferative zones. The identification of brain tumour stem cells has important implications for understanding brain tumour biology and these cells may be critical cellular targets for curative therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.