ArticleMethods (San Diego, Calif.)2007
Using atomic force microscopy to study chromatin structure and nucleosome remodeling.
Article in Methods (San Diego, Calif.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Multiscale modeling primer: Focus on chromatin and epigenetics.The Journal of biological chemistry · 2026Review
- Nano-Surveillance: Tracking Individual Molecules in a Sea of Chromatin.Journal of molecular biology · 2021Review
- Size-Independent Transmembrane Transporting of Single Tetrahedral DNA Nanostructures.Global challenges (Hoboken, NJ) · 2020Article
- Direct measurement of the mechanical properties of a chromatin analog and the epigenetic effects of para-sulphonato-calix[4]arene.Scientific reports · 2019Article
- Article
- Local DNA Sequence Controls Asymmetry of DNA Unwrapping from Nucleosome Core Particles.Biophysical journal · 2018Article
- The Process of Wrapping Virus Revealed by a Force Tracing Technique and Simulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Concerted Flexibility of Chromatin Structure, Methylome, and Histone Modifications along with Plant Stress Responses.Biology · 2017Review
- Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2.Scientific reports · 2016Article
- Visualizing the Path of DNA through Proteins Using DREEM Imaging.Molecular cell · 2016Article
- In Vitro Chromatin Assembly: Strategies and Quality Control.Methods in enzymology · 2016Article
- Imaging and force measurement of LDL and HDL by AFM in air and liquid.FEBS open bio · 2015Article
- Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA.Journal of visualized experiments : JoVE · 2013Article
- The Myb/SANT domain of the telomere-binding protein TRF2 alters chromatin structure.Nucleic acids research · 2009Article
- Chromatin stability at low concentration depends on histone octamer saturation levels.Biophysical journal · 2009Article
- Single-epitope recognition imaging of native chromatin.Epigenetics & chromatin · 2008Article
- Article
- Two-component atomic force microscopy recognition imaging of complex samples.Analytical biochemistry · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Atomic force microscopy (AFM) is a technique that can directly image single molecules in solution and it therefore provides a powerful tool for obtaining unique insights into the basic properties of biological materials and the functional processes in which they are involved. We have used AFM to analyze basic features of nucleosomes in arrays, such as DNA-histone binding strength, cooperativity in template occupation, nucleosome stabilities, nucleosome locations and the effects of acetylation, to compare these features in different types of arrays and to track the response of array nucleosomes to the action of the human Swi-Snf ATP-dependent nucleosome remodeling complex. These experiments required several specific adaptations of basic AFM methods, such as repetitive imaging of the same fields of molecules in liquid, the ability to change the environmental conditions of the sample being imaged and detection of specific types of molecules within compositionally complex samples. Here, we describe the techniques that allowed such analyses to be carried out.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.