ArticleThe Journal of experimental medicine1992
Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 245 citations in OpenAlex.
- Trial
- Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.The Journal of clinical investigation · 1993Trial
- The Enigma of Eosinophil Degranulation.International journal of molecular sciences · 2021Review
- Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV.Journal of the American Heart Association · 2020Article
- Eosinophils in Eosinophilic Esophagitis: The Road to Fibrostenosis is Paved With Good Intentions.Frontiers in immunology · 2020Review
- Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder.Frontiers in immunology · 2020Review
- The use of biologics for immune modulation in allergic disease.The Journal of clinical investigation · 2019Review
- Interleukin-5 Antagonists Usher in a New Generation of Asthma Therapy.Current allergy and asthma reports · 2016Review
- Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay.Diagnostic pathology · 2014Article
- NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells.Cytotechnology · 2014Article
- Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity.Frontiers in immunology · 2014Review
- Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field.Expert review of hematology · 2012Review
- Immunoregulatory roles of eosinophils: a new look at a familiar cell.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2008Review
- An autosomal genome-wide screen for celiac disease in Bedouin families.Genes and immunity · 2008Article
- Proteins specifically hyperexpressed in a coeliac disease patient with aberrant T cells.Clinical and experimental immunology · 2007Article
- The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease.Clinical and experimental immunology · 2005Article
- The multi-organ origin of interleukin-5 in the mouse.Leukemia · 2001Article
- Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma): inhibition by immunoglobulin a complexes.The Journal of experimental medicine · 1999Article
- Improvement of eosinophilic heart disease after steroid therapy: successful demonstration by endomyocardial biopsied specimens.Heart and vessels · 1999Article
- Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33.American journal of human genetics · 1998Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 5 (IL-5), the major factor involved in eosinophil differentiation, is produced by T cells or mast cells. In the present study, we found that eosinophils infiltrating the mucosa of four patients with active coeliac disease also express the IL-5 mRNA. No positive signal was obtained in normal duodenum tissues and in the cell infiltrate from patients submitted to gluten restriction. The identification of labeled mucosal cells as eosinophils relied on their typical morphology. Moreover, highly purified blood eosinophils from three out of four patients with eosinophilia were also strongly labeled with the IL-5 antisense but not with the corresponding sense probe. Together, these results suggest that eosinophils have the capacity to synthesize IL-5, which could contribute to paracrine interactions with T and B cells and, in autocrine fashion, locally participate, through binding to the IL-5 receptor, to eosinophil differentiation and activation. These data might have implications not only in the pathology of coeliac disease but also in other diseases associated with eosinophil infiltration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.