ArticleThe Journal of experimental medicine1992
A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 133 citations in OpenAlex.
- Prominent transcriptomic changes in Mycobacterium intracellulare under acidic and oxidative stress.BMC genomics · 2024Article
- Role of Subunit Exchange and Electrostatic Interactions on the Chaperone Activity of Mycobacterium leprae HSP18.PloS one · 2015Article
- IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy.PLoS neglected tropical diseases · 2014Article
- Analysis of antigens of Mycobacterium leprae by interaction to sera IgG, IgM, and IgA response to improve diagnosis of leprosy.BioMed research international · 2014Review
- The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy.PLoS neglected tropical diseases · 2014Article
- Identification of mimotopes of Mycobacterium leprae as potential diagnostic reagents.BMC infectious diseases · 2013Article
- Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses.The Journal of biological chemistry · 2011Article
- Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.Clinical and vaccine immunology : CVI · 2011Article
- In infertile women, cells from Chlamydia trachomatis infected sites release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat-shock-protein stimulation than fertile women.Reproductive biology and endocrinology : RB&E · 2008Article
- Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Regulation of human T-cell homing receptor expression in cutaneous bacterial infection.Immunology · 2007Article
- Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion.Immunology · 2007Article
- Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles.Infection and immunity · 2006Article
- The continuing challenges of leprosy.Clinical microbiology reviews · 2006Review
- Article
- Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.The Journal of clinical investigation · 2004Article
- Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.Infection and immunity · 2002Article
- Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.Clinical and diagnostic laboratory immunology · 2001Article
- Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease.Infection and immunity · 2000Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Several mycobacterial antigens, identified by monoclonal antibodies and patient sera, have been found to be homologous to stress or heat-shock proteins (hsp) defined in Escherichia coli and yeast. A major antigen recognized by most Mycobacterium leprae-reactive human T cell lines and cell wall-reactive T cell clones is a 10-kD protein that has now been cloned and sequenced. The predicted amino acid sequence of this protein is 44% homologous to the hsp 10 (GroES) of E. coli. The purified native and recombinant 10-kD protein was found to be a stronger stimulator of peripheral blood T cell proliferation than other native and recombinant M. leprae proteins tested. The degree of reactivity paralleled the response to intact M. leprae throughout the spectrum of leprosy. Limiting-dilution analysis of peripheral blood lymphocytes from a patient contact and a tuberculoid patient indicated that approximately one third of M. leprae-reactive T cell precursors responded to the 10-kD antigen. T cell lines derived from lepromin skin tests were strongly responsive to the 10-kD protein. T cell clones reactive to both the purified native and recombinant 10-kD antigens recognized M. leprae-specific epitopes as well as epitopes crossreactive with the cognate antigen of M. tuberculosis. Further, the purified hsp 10 elicited strong delayed-type hypersensitivity reactions in guinea pigs sensitized to M. leprae. The strong T cell responses against the M. leprae 10-kD protein suggest a role for this heat-shock cognate protein in the protective/resistant responses to infection.
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