ArticleAccounts of chemical research2007
Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems.
Article in Accounts of chemical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The Impact of Secondary Structure on the Base-Filling of N-Methoxy-1,3-Oxazinane (MOANA) and N-Methoxy-1,3-Oxazolidine Glycol Nucleic Acid (MOGNA) Oligonucleotides.Chembiochem : a European journal of chemical biology · 2025Article
- Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling.Journal of the American Chemical Society · 2022Article
- Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly.Chemical Society reviews · 2021Review
- Synthetic Life with Alternative Nucleic Acids as Genetic Materials.Molecules (Basel, Switzerland) · 2020Review
- Probing of Nucleic Acid Structures, Dynamics, and Interactions With Environment-Sensitive Fluorescent Labels.Frontiers in chemistry · 2020Review
- Artificial Sandwich Base for Monitoring Single-Nucleobase Changes and Charge-Transfer Rates in DNA.Analytical chemistry · 2019Article
- The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.Antiviral research · 2018Review
- Artificial Base zT as Functional "Element" for Constructing Photoresponsive DNA Nanomolecules.Journal of the American Chemical Society · 2017Article
- Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.Molecules (Basel, Switzerland) · 2016Article
- The expanded genetic alphabet.Angewandte Chemie (International ed. in English) · 2015Review
- Binding-induced, turn-on fluorescence of the EGFR/ERBB kinase inhibitor, lapatinib.Organic & biomolecular chemistry · 2015Article
- Emission tuning of fluorescent kinase inhibitors: conjugation length and substituent effects.The Journal of organic chemistry · 2014Article
- Nucleoside triphosphates--from synthesis to biochemical characterization.Journal of visualized experiments : JoVE · 2014Article
- Preparing synthetic biology for the world.Frontiers in microbiology · 2013Article
- A fluorescent reporter of ATP binding-competent receptor kinases.Bioorganic & medicinal chemistry letters · 2012Article
- Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.ACS chemical biology · 2012Article
- Synthetic constructs in/for the environment: managing the interplay between natural and engineered Biology.FEBS letters · 2012Review
- DNA-multichromophore systems.Chemical reviews · 2012Review
- Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues.Bioorganic & medicinal chemistry · 2012Article
- Encoding phenotype in bacteria with an alternative genetic set.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We describe the design, synthesis, and properties of DNA-like molecules in which the base pairs are expanded by benzo homologation. The resulting size-expanded genetic helices are called xDNA ("expanded DNA") and yDNA ("wide DNA"). The large component bases are fluorescent, and they display high stacking affinity. When singly substituted into natural DNA, they are destabilizing because the benzo-expanded base pair size is too large for the natural helix. However, when all base pairs are expanded, xDNA and yDNA form highly stable, sequence-selective double helices. The size-expanded DNAs are candidates for components of new, functioning genetic systems. In addition, the fluorescence of expanded DNA bases makes them potentially useful in probing nucleic acids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.