Trial reportPediatric cardiology
Effect of microalbuminuria lowering on regression of left ventricular hypertrophy in children and adolescents with essential hypertension.
Trial report in Pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Renin-Angiotensin System in Pediatric Primary Hypertension (PHRAS)
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE): The Role of Angiotensin-(1-7) in Hypertension and Hypertension-Induced Heart and Kidney Damage
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- Pharmacological interventions for hypertension in children.The Cochrane database of systematic reviews · 2014Pooled it
- Renal complications in pediatric sickle cell disease: results from a single-center study.Annals of hematology · 2026Article
- Hidden burden of hypertension in Arab adolescents linked to obesity, dyslipidemia, and vitamin D status.Scientific reports · 2025Article
- Etiology and Medication of Hospitalized Children With Hypertension: A Retrospective Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.Kidney research and clinical practice · 2025Article
- Antihypertensives in Children and Adolescents.Current hypertension reports · 2022Review
- Cardiovascular risk in children: a burden for future generations.Italian journal of pediatrics · 2022Review
- Under-recognition of pediatric hypertension diagnosis: Examination of 1 year of visits to community health centers.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- The predictive value of repeated blood pressure measurements in childhood for cardiovascular risk in adults: the Hanzhong Adolescent Hypertension Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Hypertensive Crisis in Pediatric Patients: An Overview.Frontiers in pediatrics · 2020Review
- Pediatric Hypertension: Parent Perspectives.Global pediatric health · 2020Article
- Management of high blood pressure in children: similarities and differences between US and European guidelines.Pediatric nephrology (Berlin, Germany) · 2019Review
- Hypertension and its severity in children with steroid sensitive nephrotic syndrome during remission.Clinical and experimental nephrology · 2018Article
- Why should we screen for arterial hypertension in children and adolescents?Pediatric nephrology (Berlin, Germany) · 2018Review
- Albuminuria and kidney function as prognostic marker of left ventricular mass among South Asians with hypertension.Journal of the American Society of Hypertension : JASH · 2017Article
- Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review.Frontiers in pediatrics · 2017Review
- Pediatric Hypertension: Provider Perspectives.Global pediatric health · 2017Article
- Microalbuminuria in Children With Primary Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Prehypertension: a warning sign of future cardiovascular risk.International journal of preventive medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microalbuminuria (MA) is associated with increased cardiovascular risk in adult hypertensive patients, but no study has specifically examined the effects of MA lowering on regression of left ventricular hypertrophy (LVH) among pediatric patients with hypertension. Fifty-five patients with essential hypertension, 11-19 years old, were prospectively studied. All patients received concomitant therapy of hydrochlorothiazide and angiotensin-converting enzyme inhibitor. Five patients also required angiotensin receptor blocker to achieve the blood pressure goal. Baseline and 12-month follow-up measures of left ventricular mass index (LVMI), determined by echocardiography and urine microalbumin/creatinine ratio (MA/Cr), were collected. MA was defined as MA/Cr >30 microg/mg. LVH was defined as LVMI >38.6 g/m(2.7). The primary end points were reductions in MA and LVMI of 25% or more. Weight (r = 0.83), body surface area (r = 0.85), body mass index (BMI) (r = 0.86), systolic blood pressure (SBP) (r = 0.57), diastolic blood pressure (DBF) (r = 0.49), mean arterial pressure (r = 0.53) and MA (r= 0.87) were all univariate correlates of LVMI. In a multiple regression analysis, MA, BMI and SBP were significant correlates of LVMI. MA alone explained 76% of the variance of LVMI, whereas BMI and SBP explained only 1.6 and 0.4% of the variance, respectively. MA was the most significant correlate of follow-up LVMI after BMI and SBP were included in the overall multiple regression models. Thus, MA is a strong predictor of LVH in hypertensive children and adolescents. MA lowering halts the progression of LVH or induces its regression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.