ArticleCancer research2007
TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation.
Article in Cancer research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma.Research (Washington, D.C.) · 2025Article
- Role of TSC1 in physiology and diseases.Molecular and cellular biochemistry · 2021Review
- Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation.PLoS biology · 2020Article
- New insights into the biology of acute myeloid leukemia with mutated NPM1.International journal of hematology · 2019Review
- The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis.FASEB bioAdvances · 2019Article
- mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation.Cell cycle (Georgetown, Tex.) · 2016Article
- Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia.Scientific reports · 2015Article
- Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.BioMed research international · 2015Article
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.Nature cell biology · 2013Article
- The determinants of head and neck cancer: Unmasking the PI3K pathway mutations.Journal of carcinogenesis & mutagenesis · 2013Article
- Deconvoluting mTOR biology.Cell cycle (Georgetown, Tex.) · 2012Review
- Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.Molecular and cellular biology · 2012Article
- RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.Cancer research · 2011Article
- Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis.Neuroscience letters · 2011Review
- Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation.Oncogene · 2011Article
- Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.The Journal of biological chemistry · 2010Article
- Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies.Epilepsia · 2010Review
- Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.Oncogene · 2009Article
- Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.Molecular and cellular biology · 2008Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Nucleophosmin (B23) is a nucleolar phosphoprotein that has been implicated in numerous cellular processes. In particular, nucleophosmin interacts with nucleolar components of newly synthesized ribosomes to promote ribosome nuclear export. Nucleophosmin is a classic mitogen-induced protein, with changes in its expression correlating with growth factor stimulation. In this study, we examined the underlying mechanism of nucleophosmin induction and showed that hyperproliferative signals emanating from oncogenic H-Ras(V12) cause tremendous increases in nucleophosmin protein expression. Nucleophosmin protein accumulation was dependent on mammalian target of rapamycin (mTOR) activation, as rapamycin completely prevented nucleophosmin induction. Consistent with this finding, genetic ablation of Tsc1, a major upstream inhibitor of mTOR, resulted in nucleophosmin protein induction through increased translation of existing nucleophosmin mRNAs. Increases in nucleophosmin protein accumulation were suppressed by reintroduction of TSC1. Induction of nucleophosmin through Tsc1 loss resulted in a greater pool of actively translating ribosomes in the cytoplasm, higher overall rates of protein synthesis, and increased cell proliferation, all of which were dependent on efficient nucleophosmin nuclear export. Nucleophosmin protein accumulation in the absence of Tsc1 promoted the nuclear export of maturing ribosome subunits, providing a mechanistic link between TSC1/mTOR signaling, nucleophosmin-mediated nuclear export of ribosome subunits, protein synthesis levels, and cell growth.
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