ArticleInfection and immunity2007
Gingival epithelial cell transcriptional responses to commensal and opportunistic oral microbial species.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of oral health education on the incidence and severity of oral mucositis in pediatric cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Dysregulated genes in HIGK-treatedMolecular biology research communications · 2025Article
- Insights into the enigma of oral streptococci in carcinogenesis.Microbiology and molecular biology reviews : MMBR · 2024Review
- Oral streptococci: modulators of health and disease.Frontiers in cellular and infection microbiology · 2024Review
- Oral Commensal Streptococci: Gatekeepers of the Oral Cavity.Journal of bacteriology · 2022Review
- The Regulatory Effect of Coaggregation BetweenFrontiers in cellular and infection microbiology · 2022Article
- Stable reconstructed human gingiva-microbe interaction model: Differential response to commensals and pathogens.Frontiers in cellular and infection microbiology · 2022Article
- The effectiveness of an oral health education and prevention program on the incidence and severity of oral mucositis in pediatric cancer patients: a non-randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Immunomodulatory streptococci that inhibit CXCL8 secretion and NFκB activation are common members of the oral microbiota.Journal of medical microbiology · 2021Article
- In Vitro Effects ofCells · 2020Article
- Effects of Oral Commensal Streptococci onDentistry journal · 2020Article
- Flavorless vs. Flavored Electronic Cigarette-Generated Aerosol and E-Liquid on the Growth of Common Oral Commensal Streptococci.Frontiers in physiology · 2020Article
- Screening of Health-Associated Oral Bacteria for Anticancer PropertiesFrontiers in cellular and infection microbiology · 2020Article
- Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model.Cellular microbiology · 2019Article
- The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease.Journal of molecular biology · 2019Review
- A Comparison of Flavorless Electronic Cigarette-Generated Aerosol and Conventional Cigarette Smoke on the Survival and Growth of Common Oral CommensalInternational journal of environmental research and public health · 2019Article
- Streptococcus sanguinis biofilm formation & interaction with oral pathogens.Future microbiology · 2018Review
- The epithelial cell response to health and disease associated oral biofilm models.Journal of periodontal research · 2017Article
- Porphyromonas gingivalis activates NFκB and MAPK pathways in human oral epithelial cells.BMC immunology · 2017Article
- The making of a miscreant: tobacco smoke and the creation of pathogen-rich biofilms.NPJ biofilms and microbiomes · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Transcriptional profiling and ontology tools were utilized to define the biological pathways of gingival epithelial cells modulated by coculture with the oral commensal Streptococcus gordonii and the opportunistic commensal Fusobacterium nucleatum. Overall, F. nucleatum and S. gordonii perturbed the gingival epithelial cell transcriptome much less significantly than the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans perturbed the transcriptome, indicating that there was a greater degree of host adaptation by the commensal species (M. Handfield, J. J. Mans, G. Zheng, M. C. Lopez, S. Mao, A. Progulske-Fox, G. Narasimhan, H. V. Baker, and R. J. Lamont, Cell. Microbiol. 7:811-823, 2005). The biological pathways significantly impacted by F. nucleatum and S. gordonii included the mitogen-activated protein kinase (MAPK) and Toll-like receptor signaling pathways. Differential regulation of GADD45 and DUSP4, key components of the MAPK pathway, was confirmed at the protein level by Western blotting. Modulation of the MAPK pathway is likely to affect host cell proliferation and differentiation. In addition, both the MAPK and Toll-like receptor pathways ultimately converge on cytokine gene expression. An enzyme-linked immunosorbent assay of secreted interleukin-6 (IL-6) and IL-8 demonstrated that F. nucleatum induced production of these cytokines, whereas S. gordonii inhibited secretion from the epithelial cells. Stimulation of secretion of proinflammatory cytokines from epithelial cells may reflect the invasive phenotype of F. nucleatum and contribute to the greater pathogenic potential of F. nucleatum than of S. gordonii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.