ArticleInfection and immunity2007
Primary infection of C57BL/6 mice with Plasmodium yoelii induces a heterogeneous response of NKT cells.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- More time to kill: A longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria.iScience · 2023Article
- The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection.Pathogens (Basel, Switzerland) · 2023Review
- Review
- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- NK1.1 Expression Defines a Population of CD4Frontiers in immunology · 2018Article
- Malaria-Cutaneous Leishmaniasis Co-infection: Influence on Disease Outcomes and Immune Response.Frontiers in microbiology · 2016Article
- The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development.Scientific reports · 2015Article
- The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products.Frontiers in immunology · 2015Review
- HLA class II (DR0401) molecules induce Foxp3+ regulatory T cell suppression of B cells in Plasmodium yoelii strain 17XNL malaria.Infection and immunity · 2014Article
- Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection.PloS one · 2013Article
- Targeting the diverse immunological functions expressed by hepatic NKT cells.Expert opinion on therapeutic targets · 2011Review
- Comparative analysis of activation phenotype, proliferation, and IFN-gamma production by spleen NK1.1(+) and NK1.1(-) T cells during Plasmodium chabaudi AS malaria.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.Seminars in immunology · 2010Review
- Article
- An early burst of IFN-gamma induced by the pre-erythrocytic stage favours Plasmodium yoelii parasitaemia in B6 mice.Malaria journal · 2009Article
- Experimental malaria infection triggers early expansion of natural killer cells.Infection and immunity · 2008Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NKT cells are a population of innate-like lymphocytes that display effector functions and immunoregulatory properties. We characterized the NKT cell response induced in C57BL/6 mice during a primary infection with Plasmodium yoelii sporozoites. We observed a heterogeneous NKT cell response that differed between liver and spleen. Hepatic NKT cells found in infected livers consisted mainly of CD1d-dependent CD4+ and double-negative (DN) NKT cells, whereas CD1d-independent NKT cells exhibiting a TCR(high) CD4(high) phenotype were prominent among splenic NKT cells during the infection. Hepatic and splenic NKT cells isolated from infected mice were activated and secreted mainly gamma interferon and tumor necrosis factor alpha in response to stimulation. Finally, P. yoelii-activated hepatic DN NKT cells inhibited the parasite's liver stage in a CD1d-dependent manner in vitro. However, experiments using B6.CD1d-deficient mice showed that CD1d and CD1d-restricted NKT cells are not necessary to control the parasite's development in vivo during neither the preerythrocytic stage nor the erythrocytic stage. Thus, our results show that a primary P. yoelii infection induces a heterogeneous and organ-specific response of NKT cells and that CD1d-dependent NKT cells play a minor role in the control of the development of Plasmodium in vivo in our model.
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