ArticleBiophysical journal2007
Metastability of microtubules induced by competing internal forces.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Mechanics and kinetics of dynamic instability.eLife · 2020Article
- Statistical mechanics provides novel insights into microtubule stability and mechanism of shrinkage.PLoS computational biology · 2015Article
- Conformational mechanism for the stability of microtubule-kinetochore attachments.Biophysical journal · 2014Article
- Cooperative lattice dynamics and anomalous fluctuations of microtubules.European biophysics journal : EBJ · 2012Article
- Dynamic instability of a growing adsorbed polymorphic filament.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent modeling efforts to estimate energies of tubulin-tubulin bonds shed light on a delicate balance between competing mechanical forces maintaining microtubule walls. Here we formulate two important refinements to the explanation of bond energetics. First, energy surface calculations in the elastic filament approximation reveal a finite stabilizing barrier assumed a simple Lennard-Jones-like potential for protein bonds. The presence of a guanosine triphosphate (GTP) cap represented by straight segments is necessary, as it is predicted for a long time. In the lack of such a cap, the protofilaments are either in an absolutely stable or absolutely unstable state. Second, our calculations show that this barrier appears only if the mechanical energy associated with the conformational change after GTP hydrolysis (curling energy) is larger than the strength of lateral bonds. The overall energy balance we propose supports continuous assembly of GTP dimers, a metastable state in the presence of a finite GTP cap and energetically driven disassembly of guanosine diphosphate protofilaments.
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Registered trials
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