ArticleThe Journal of cell biology1992
Clusters of neural cell adhesion molecule at sites of cell-cell contact.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 37 citations in OpenAlex.
- Regulation of HLA-DR and co-stimulatory molecule expression on natural killer T cells by granulocyte-macrophage colony-stimulating factor.Immunology · 2002Article
- Expression cloning of the Golgi CMP-sialic acid transporter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Characterization of neural cell adhesion molecule (NCAM) expression in thyroid follicular cells: induction by cytokines and over-expression in autoimmune glands.Clinical and experimental immunology · 1994Article
- Differential effects of over-expressed neural cell adhesion molecule isoforms on myoblast fusion.The Journal of cell biology · 1993Article
- Apical polarization of N-CAM in retinal pigment epithelium is dependent on contact with the neural retina.The Journal of cell biology · 1993Article
- Induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Sequence-specific impairment of memory formation by NCAM antisense oligonucleotides.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
I have examined the distribution of neural cell adhesion molecule (N-CAM) in cultured C2 myogenic cells and other cell lines to determine if N-CAM accumulates at sites of cell-cell contact. C2 cells growing in log phase display large clusters of neural cell adhesion molecule where they contact each other. These clusters are remarkably stable, do not form at cell-substrate contacts, and appear not to be enriched in a number of other cytoskeletal, membrane, or extracellular proteins. Thus, N-CAM clusters form preferentially in response to cell-cell contact and are specifically enriched in N-CAM. As C2 cultures mature and differentiate, clusters persist at contacts between aligning myoblasts and between myotubes, consistent with a role in myogenesis. N-CAM is also enriched at cell-cell contacts in cultures of PC12, NRK, and CHO cells. These cells have significant amounts of N-CAM as detected on immunoblots. Clusters are not seen in L929 cells, which do not have detectable amounts of N-CAM. Coculture of these cells with C2 cells results in the clustering of N-CAM at heterologous contacts between C2 cells and NRK, CHO, or PC12 cells, but not between C2 cells and L929 cells. These results suggest that N-CAM specifically accumulates where N-CAM-bearing cells contact one another. Clustering of N-CAM may be an important step in strengthening intercellular adhesion.
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Registered trials
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