ArticleThe Journal of pediatrics2007
Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics.
Article in The Journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04684667 ('' Efficacy of Propranolol in the Treatment of Infantile Hemangioma"), which is not on this map. Cited by 119 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
'' Efficacy of Propranolol in the Treatment of Infantile Hemangioma"
Who cites it
119 citing papers in PubMed, 4 syntheses or guidelines pooled it, 477 citations in OpenAlex.
- Efficacy and adverse effects of oral propranolol in infantile hemangioma: a meta-analysis of comparative studies.World journal of pediatrics : WJP · 2019Pooled it
- Beta-blockers versus corticosteroids in the treatment of infantile hemangioma: an evidence-based systematic review.World journal of pediatrics : WJP · 2013Pooled it
- Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis.European journal of pediatrics · 2013Pooled it
- Propranolol is an effective treatment for airway haemangiomas: a critical analysis and meta-analysis of published interventional studies.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2012Pooled it
- To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.Indian journal of ophthalmology · 2019Trial
- The expression and function of miR-424 in infantile skin hemangioma and its mechanism.Scientific reports · 2017Trial
- Assessment of Infantile Hemangiomas Using a Handheld Wireless Diffuse Optical Spectroscopic Device.Pediatric dermatology · 2017Trial
- Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial.JAMA dermatology · 2017Trial
- Article
- Infantile fibrosarcoma of the left upper limb mimicking a hemangioma: A case report.International journal of surgery case reports · 2025Article
- Hemangioma of the abdominal wall in infancy.Journal of surgical case reports · 2025Article
- Minimally invasive treatment of benign oral vascular lesions: A retrospective study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Orbital Intra-osseous Infantile Haemangioma in an 8-month-old Infant: A Case Report.Acta dermato-venereologica · 2025Article
- Mesenchymal Tumors of the Liver: An Update Review.Biomedicines · 2025Review
- Efficacy of the 595 nm pulsed dye laser in the treatment of hemangiomas in Vietnamese patients.Lasers in medical science · 2025Article
- Paediatric Head and Neck Hemangiomas: Scopes, Challenges and Outcome of Surgical Management.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors.Frontiers in cell and developmental biology · 2025Review
- Digital Imaging and Artificial Intelligence in Infantile Hemangioma: A Systematic Literature Review.Biomimetics (Basel, Switzerland) · 2024Review
- A rare case of a 5-year-old girl with Klippel-Trénaunay syndrome and a bleeding focal vulvar hemangioma in Uganda.Clinical case reports · 2024Article
- Placental ACE2 Expression: A Possible Pathogenetic Mechanism for Infantile Hemangiomas.Dermatopathology (Basel, Switzerland) · 2024Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by[Drugs news].2015
Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo characterize demographic, prenatal, and perinatal features of patients with infantile hemangiomas and to determine the importance of these factors in predicting rates of complication and treatment. STUDY
designWe conducted a prospective study at 7 U.S. pediatric dermatology clinics. A consecutive sample of 1058 children, aged 12 years and younger, with infantile hemangiomas was enrolled between September 2002 and October 2003. A standardized questionnaire was used to collect demographic, prenatal, perinatal, and hemangioma-specific data. National Vital Statistic System Data (NVSS) was used to compare demographic variables and relevant rates of prenatal events.
resultsIn comparison with the 2002 United States National Vital Statistics System birth data, we found that infants with hemangiomas were more likely to be female, white non-Hispanic, premature (P < .0001) and the product of a multiple gestation (10.6% versus 3.1%; P < .001). Maternal age was significantly higher (P < .0001), and placenta previa (3.1%) and pre-eclampsia (11.8%) were more common.
conclusionsInfants with hemangiomas are more likely to be female, white non-Hispanic, premature, and products of multiple gestations. Prenatal associations include older maternal age, placenta previa, and pre-eclampsia. No demographic, prenatal, and perinatal factors predicted higher rates of complications or need for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.