ArticleBiophysical chemistry2007
Continuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models.
Article in Biophysical chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions.PLoS computational biology · 2020Article
- Improvements to the APBS biomolecular solvation software suite.Protein science : a publication of the Protein Society · 2018Article
- Multi-Scale Continuum Modeling of Biological Processes: From Molecular Electro-Diffusion to Sub-Cellular Signaling Transduction.Computational science & discovery · 2012Article
- Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries.Frontiers in physiology · 2012Article
- Differential geometry based solvation model II: Lagrangian formulation.Journal of mathematical biology · 2011Article
- A new 3D mass diffusion-reaction model in the neuromuscular junction.Journal of computational neuroscience · 2011Article
- Diffusion and association processes in biological systems: theory, computation and experiment.BMC biophysics · 2011Article
- A solvable model for the diffusion and reaction of neurotransmitters in a synaptic junction.BMC biophysics · 2011Article
- MIBPB: a software package for electrostatic analysis.Journal of computational chemistry · 2011Article
- Differential geometry based solvation model I: Eulerian formulation.Journal of computational physics · 2010Article
- Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum.PLoS computational biology · 2010Article
- Finite element analysis of drug electrostatic diffusion: inhibition rate studies in N1 neuraminidase.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2009Article
- Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian dynamics studies.Biophysical journal · 2008Article
- Characterization of a complete cycle of acetylcholinesterase catalysis by ab initio QM/MM modeling.Journal of molecular modeling · 2008Article
- Structural answers and persistent questions about how nicotinic receptors work.Frontiers in bioscience : a journal and virtual library · 2008Review
- Finite element analysis of the time-dependent Smoluchowski equation for acetylcholinesterase reaction rate calculations.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The reaction-diffusion system of the neuromuscular junction has been modeled in 3D using the finite element package FEtk. The numerical solution of the dynamics of acetylcholine with the detailed reaction processes of acetylcholinesterases and nicotinic acetylcholine receptors has been discussed with the reaction-determined boundary conditions. The simulation results describe the detailed acetylcholine hydrolysis process, and reveal the time-dependent interconversion of the closed and open states of the acetylcholine receptors as well as the percentages of unliganded/monoliganded/diliganded states during the neuro-transmission. The finite element method has demonstrated its flexibility and robustness in modeling large biological systems.
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