ArticleGene expression patterns : GEP2007
Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube.
Article in Gene expression patterns : GEP, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.G3 (Bethesda, Md.) · 2026Article
- A Knock-in Zebrafish Reporter Line for Live Visualization of Endogenous Olig2 Protein Dynamics.Zebrafish · 2025Article
- Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Zebrafish sall1a and sall4 contribute to body elongation.Developmental biology · 2025Article
- The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements.Development, growth & differentiation · 2021Article
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- Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord.Scientific reports · 2021Article
- Evolutionary Origins of the Oligodendrocyte Cell Type and Adaptive Myelination.Frontiers in neuroscience · 2021Review
- Intracellular Calcium Mobilization Is Required for Sonic Hedgehog Signaling.Developmental cell · 2018Article
- Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord?Journal of developmental biology · 2017Review
- Regeneration of Zebrafish CNS: Adult Neurogenesis.Neural plasticity · 2016Review
- prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements.Developmental biology · 2014Article
- Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain.PloS one · 2014Article
- Embryonic exposure to excess thyroid hormone causes thyrotrope cell death.The Journal of clinical investigation · 2014Article
- Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish.PloS one · 2014Article
- Parallel evolution of chordate cis-regulatory code for development.PLoS genetics · 2013Article
- Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development.Biology open · 2013Article
- Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord.PLoS genetics · 2012Article
- Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.Development (Cambridge, England) · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Sonic Hedgehog (Shh) signaling helps pattern the vertebrate neural tube, in part by regulating the dorsal/ventral expression of a number of homeodomain containing transcription factors. These Hh responsive genes have been divided into two classes, with Class II genes being activated by Hh signaling and Class I genes being repressed by Hh signaling. While the transcriptional response to varying Hh levels is well defined in chick and mouse, it is only partially described in zebrafish, despite the fact that zebrafish has emerged as a powerful genetic system for the study of neural patterning. To better characterize the Hh response in the zebrafish neural tube, we cloned the zebrafish Class II Hh target genes nkx2.9 and nkx6.2. We then analyzed the expression of a number of Class I and Class II Hh responsive genes in wild type, Hh mutant, and Hh over-expressing zebrafish embryos. We show that expression of Class I and Class II genes is highly conserved in the vertebrate neural tube. Further, ventral-most Class II gene expression was completely lost in all Hh pathway mutants analyzed, indicating high levels of Hh signaling are blocked in all of these mutants. In contrast, more dorsally expressed genes were variably affected in different Hh pathway mutants, indicating mid-levels of Hh signaling are differentially affected. This comprehensive expression study provides an important tool for the characterization of Hh signaling in zebrafish and provides a sensitive assay for determining the degree to which newly identified zebrafish mutants affect Hh signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.