ArticleMicrobial pathogenesis2007
Cytotoxic and cytokine-inducing properties of Candida glabrata in single and mixed oral infection models.
Article in Microbial pathogenesis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Divergent Approaches to Virulence inInternational journal of molecular sciences · 2019Review
- Article
- Microevolution of the pathogenic yeastsMicrobial cell (Graz, Austria) · 2019Review
- Chemotherapy-induced oral mucositis and associated infections in a novel organotypic model.Molecular oral microbiology · 2018Article
- A Host-Pathogen Interaction Screen IdentifiesG3 (Bethesda, Md.) · 2018Article
- Candida-Epithelial Interactions.Journal of fungi (Basel, Switzerland) · 2018Review
- Innate Immunity to Mucosal Candida Infections.Journal of fungi (Basel, Switzerland) · 2017Review
- Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis.PLoS pathogens · 2016Article
- Effects of bovine lactoferrin to oral Candida albicans and Candida glabrata isolates recovered from the saliva in elderly people.Odontology · 2015Article
- Two unlike cousins: Candida albicans and C. glabrata infection strategies.Cellular microbiology · 2013Review
- Anticandidal activity and biocompatibility of a rechargeable antifungal denture material.Oral diseases · 2013Article
- Antibacterial effects of blackberry extract target periodontopathogens.Journal of periodontal research · 2013Article
- Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae.Medical microbiology and immunology · 2012Article
- Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.Infection and immunity · 2010Article
- Epithelial GM-CSF induction by Candida glabrata.Journal of dental research · 2009Article
- Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis.Expert reviews in molecular medicine · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oral candidiasis is a common opportunistic infection, with Candida albicans being the most prevalent etiologic agent and Candida glabrata emerging as an important pathogen. C. glabrata is frequently co-isolated with C. albicans from oral lesions. Although C. albicans has been shown to trigger significant cytokine responses and cell damage, C. glabrata has not been systematically studied yet. The purpose of this study was to characterize the ability of C. glabrata to induce proinflammatory cytokine responses and host damage as a single infecting organism and in combination with C. albicans, using in vitro models of the oral mucosa. In monolayer oral epithelial cell cultures, C. glabrata failed to induce a significant interleukin-1alpha and interleukin-8 cytokine response and showed lower cytotoxicity, compared to C. albicans. However, C. glabrata triggered a significantly higher granulocyte macrophage colony stimulating factor response than C. albicans. C. glabrata strains showed a strain-dependent tissue damaging ability and a superficial invasion of the mucosal compartment in a three-dimensional (3-D) in vitro model of the human oral mucosa and submucosa. In the 3-D system, co-infection failed to promote host damage beyond the levels of infection with C. albicans alone. These studies indicate that C. glabrata induces cytokines in human oral epithelium in a strain-specific manner, but its tissue/cell damaging ability, compared to C. albicans, is low. Synergy between C. glabrata and C. albicans in cytokine induction and host damage was not observed with the strains tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.